欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的 研究4型黏蛋白（MUC4）及表皮生长因子受体（EGFR）在膀胱尿路上皮癌中的表达,探讨其相互关系及临床病理意义。方法 采用免疫组织化学法检测MUC4及EGFR蛋白在78例膀胱尿路上皮癌和13例膀胱正常黏膜中的表达。结果 膀胱尿路上皮癌组织中MUC4蛋白阳性率为52.6%,显著高于膀胱正常黏膜组织（0.0%）（〈0.05）。EGFR蛋白在膀胱尿路上皮癌组织中阳性率为60.3%,显著高于膀胱正常黏膜组织（0.0%）（〈0.05）。结论 MUC4及EGFR蛋白表达增高与膀胱尿路上皮癌的临床分期、病理分级,复发密切相关。MUC4与EGFR呈正相关。联合检测MUC4和EGFR有助于膀胱尿路上皮癌的早期诊断及判断患者预后。
英文摘要：
[Objective] To research on the expression of mucin 4 （MUC4） and epidermal growth factor re- ceptor （EGFR） proteins in bladder urothelial carcinoma （BUC）, the relation between them and their clinical significances. [Methods] The expression of MUC4 and EGFR proteins in the cancerous tissues of 78 BUC cases and the normal bladder mucosal tissues of 13 cases were detected by immunohistochemieal method. [Results] Immunohistochemical analysis showed that positive expression rates of MUC4 and EGFR proteins in the BUC tissues were 52.6% and 60.3% respectively, which were significantly higher than those in the normal bladder mueosal tissues （0.0%, 0.0%, P 〈 0.05）. [ Conclusion] Overexpression of MUC4 and EGFR proteins is closely related to the clinical stages, pathological grading and recurrence of the BUC. In addition, MUC4 and EGFR proteins are positively correlated. Detection of both MUC4 and EGFR may be useful in early diagnosis and prognosis prediction for BUC.
同期刊论文项目
同项目期刊论文
期刊信息
位置：