中文摘要：

超顺磁性氧化铁纳米粒子（SPION）作为MR负性对比剂被广泛认知,通过对其进行表面修饰,可明显提高其生物相容性与作用效果。利用外加磁场及交变电流,SPION还可具有靶向传递和磁热疗的作用。本文旨在对SPION在肝癌诊断和治疗方面的研究进展进行综述。

英文摘要：

Superparamagnetic iron oxide nanoparticles （SPION） has been known as MRI negative contrast agents. To improve its biocompatibility and effect of imaging, surface modification loading the ligand has been used to modificate the SPION. Targetting delivery and magnetic hyperthermia is allowed through the use of an external magnetic field and an al- ternating current. Research progresses of application of SPION on diagnosis and treatment of liver cancer were reviewed in this article.