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中文摘要：
凝溶胶蛋白是凝溶胶蛋白超家族的成员之一,是一种重要的肌动蛋白结合蛋白,其可通过切断、封端肌动蛋白丝,或使肌动蛋白聚集成核等方式来控制肌动蛋白的结构。凝溶胶蛋白除了在重组肌动蛋白丝中发挥作用以外,还在细胞运动、控制细胞程序性死亡等细胞活动中发挥着重要作用。本文重点回顾肌动蛋白的生物学特性、凝溶胶蛋白的基本结构和功能,以及在脓毒症患者中凝溶胶蛋白结合肌动蛋白的作用。临床上可通过监测血浆凝溶胶蛋白水平预测脓毒症患者的预后,评估脓毒症患者的病情严重程度;文章最后对外源性凝溶胶蛋白的治疗作用进行了简要介绍。
英文摘要：
Gelsolin is a member of gelsolin superfamily,which is an important actin binding protein.The gelsolin controls actin structure by severing filaments,capping filament ends and nucleating actin assembly.It occurs in a wide range of vertebrate,lower eukaryotic and plant cells,and its function is as variant as its biochemical activities.In addition to its role in actin filament remodeling,gelsolin has also other roles in several cellular processes,including cell motility,apoptosis control,and so on.In this paper,we introduced its biological features,structure,function,as well as its effect on actin binding in septic patients.The plasma gelsolin concentration is a predictor for severity and prognosis of septic patients.In addition,we introduced the therapeutic effects of exogenous gelsolin.
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