中文摘要：

目的探讨LPP（Lim domain containing preferred translocation partner in lipoma）基因多态性与中国蒙古族人群白癜风患者的遗传相关性。方法收集425例蒙古族白癜风及503例蒙古族健康对照外周血，选择位于LPP基因区域的4个单核苷酸多态性（SNP）位点（rs13076312，rs13091753，rs1464510和rs1559810），应用连接酶检测反应（Ligase detection reaction，LDR）进行基因分型。利用PLINKl．07软件进行统计分析，Х^2检验比较病例组及对照组等位基因频率及基因型频率，并计算等位基因的相对危险度估计值比值比（OR）及其95％可信区间（95％CI）。结果2个SNP（rs13076312_C，rs1464510_G）等位基因频率在白癜风组显著低于对照组（P〈0．01）。rs13076312在显性模式下，基因型频率在白癜风组与对照组间差异有统计学意义（P〈0．01），rs1464510在隐形遗传模式下，白癜风组基因型频率明显低于对照组，差异均具统计学意义（P〈0．01）。两个SNP（rs13091753和rs1559810）等位基因频率在白癜风组和对照组中差异无统计学意义（P〉0．09）。结论LPP基因多态性与蒙古族白癜风具有相关性。

英文摘要：

Objective To investigate the association of single nucleotide polymorphisms （SNP） in the LPP gene with vitiligo in Chinese Mongolian population. Methods Four hundred and twenty five Chinese Mongolians with vitiligo and 503 healthy controls were enrolled in this study. Four SNPs in LPP gene （rs13076312, rs13091753, rs1464510 and rs1559810） were genotyped by ligase detection reaction （LDR）. All statistical analyses were performed using the PLINK 1.07 software. Allele frequencies and genotype frequencies of four SNPs were compared using chi-square test （Х^2 test）. Odds ratios （OR） and 95% confidence intervals （95% CI） were estimated. Results Allele frequencies of two SNPs （rs13076312 C, rs1464510_G） in vitiligo group were significantly lower than that in the controls （P 〈 O. 01 ）. Genotype frequency of rs13076312 was lower in vitiligo than in controls in the dominant model （P 〈 0. 01 ）. Genotype frequency of rs1464510 was lower in vitiligo than the controls in the recessive model （P 〈 0.01 ）. Allele frequencies of other two SNPs （rs13091753 and rs1559810） did not show differences between vitiligo and controls （P 〉 0. 09）. Conclusion Variants in LPP gene were associated with the susceptibility of vitiligo in Chinese Mongolians.