中文摘要：

目的探讨躯体形式障碍脑静息态低频振幅（amplitude of low frequency fluctuation,ALFF）改变特点。方法纳入21例躯体形式障碍（somatoform disorders,SFD）患者和21例年龄、性别、受教育水平严格匹配的正常对照（normal control,NC）,使用3.0T磁共振扫描仪采集T2WI、T1WI结构像及静息态功能像数据。对两组受试者的ALFF map行组内和组间比较,并采用Alpha Sim（P〈0.01,体素数〉40）进行多重比较校正。然后提取差异脑区的ALFF值与临床数据进行相关性分析。结果与NC组比较,SFD组ALFF值增高的脑区有：双侧前额叶、双侧前扣带回;ALFF值减低的脑区有：右侧颞叶颞中回、左侧岛叶、左侧旁中央小叶双侧中央后回。SFD组蒙特利尔认知评估量表（Mo CA量表）评分与左侧腹内侧前额叶ALFF值呈显著负相关（r=-0.564,P=0.008）,症状自评量表（SCL-90）评分与左侧岛叶ALFF值呈显著负相关（r=-0.505,P=0.020）,病程与右侧颞叶ALFF值呈显著负相关（r=-0.514,P=0.017）。结论 SFD患者脑静息态神经元自发活动存在广泛改变,这些异常活动可部分阐释躯体形式障碍的神经生理基础。

英文摘要：

Objective To investigate the characteristics of spontaneous brain activity alterations in somatoform disorders（ SFD） by analyzing the amplitude of low-frequency fluctuation（ ALFF）. Methods A total of 21 outpatients with SFD in our clinical psychology department from June 2014 to June 2015 were recruited in the study. Another 21 normal volunteers with strictly matched ages,genders and educational levels served as control. 3. 0T MRI scanning was carried out to collect T2 WI,3D-T1 WI and resting-state functional magnetic resonance images. ALFF map within the group and between the 2 groups was analyzed by student＇s t test,with the adjustment of Alpha Sim（ P〈0. 01,clusters 〉40） for correlation of ALFF value extracted from different regions with clinical data. Results Compared with normal control,the regions with increased ALFF values were bilateral frontal lobe and bilateral anterior cingulate cortex in the SFD patients,and those with decreased ALFF values were right temporal lobe,left insula,left paracentral lobule,and bilateral postcentral gyrus. Negative correlations were found between Montreal Cognitive Assessment（ Mo CA）scores and ALFF values of the left ventromedial prefrontal cortex（ VMPFC）（ r =-0. 564,P = 0. 008）,between SCL-90 scores and ALFF values of the left insula（ r =-0. 505,P = 0. 020）,and between the disease duration and ALFF values of the right temporal lobe（ r =-0. 514,P = 0. 017） in SFD group.Conclusion Spontaneous neural activity changes exist in resting state brain of SFD patients,and these abnormal activities can partly explain the neurophysiological fundamentals of somatoform disorders.