中文摘要：

目的运用血流向量成像（VFM）技术定量分析高血压患者左心室血流能量损耗（EL）的改变，探讨EL与心脏结构和功能的关系。方法选取高血压患者52例，分为：①正常构型（NG）组，14例；②向心性重构（CR）组，20例；③向心性肥厚（CH）组，15例；④离心性肥厚（EH）组，3例（因数量太少未纳入亚组分析）。健康对照者32例。测量左室射血分数（LVEF）、左心室质量指数（LVMI）、E／e’。VFM图像上分别测得左心室不同时相、不同节段的EL。结果①EL比较：舒张晚期、等容收缩期、快速射血期，与对照组相比，高血压组左室整体以及各节段EL均增大，差异有统计学意义（P〈0．05）。高血压各亚组左室整体以及各节段EL均较正常组增大，差异有统计学意义（P〈0．05）。高血压各亚组间差异无统计学意义（P〉0．05）。②相关性分析：舒张晚期、等容收缩期以及快速射血期，左心室整体以及各节段EL均与LVMI呈显著正相关（P〈0．05）；舒张晚期、等容收缩期以及快速射血期，左心室整体以及各节段EL均与E／e’呈显著正相关（P〈0．05）；舒张晚期，左心室整体以及各节段EL均与LVEF呈显著负相关（P〈0．05）。结论VFM能够直观反映高血压患者心腔内的血流动力学改变；左心室EL与左心室质量及心脏收缩、舒张功能具有相关性。

英文摘要：

Objective To quantitatively analyze the energy loss （EL） in left ventricle with vector flow mapping （VFM） in hypertensive patients, and try to reveal the correlation of EL with cardiac structure and function. Methods Hypertension group：52 hypertensive individuals were enrolled in our study, divided into 4 subgroups：①14 patients with normal geometry（NG） ; ②20 patients with concentric remodeling（CR） ;③ 15 patients with concentric hypertrophy（CH） ;④3 patients with eccentric hypertrophy（EH）（not enrolled in subgroup analysis）. Health control group were composed of 32 healthy volunteers. LVEF, LVMI and E/e＇ were measured. And the EL in left ventricle was measured at different phases and different segments based on VFM images. Results ① EL comparison： in the phrase of late diastole （DL）, isovolumic contraction （IVC） and rapid ejection（RE）, compared with the control group, EL in entirety and each segment of left ventricle in hypertension group increased （ P 〈0.05） ;Compared with the control group, EL in entirety and each segment of left ventricle in each subgroup of hypertension increased （ P 〈0.05）;EL among different subgroups showed no statistically significant difference（ P 〉0.05）; ②Correlation analysis：in the phrase of DL, IVC and RE, EL in entirety and each segment of left ventricle showed significant positive correlations with LVMI and with E/e＇ （ P 〈0.05）. In the phrase of DL, EL in entirety and each segment of left ventricle showed significant negative correlations with LVEF （P 〈 0.05）. Conclusions EL measured quantitatively by VFM is more sensitive to reflect the changes of hemodynamic in hypertensive individuals. EL is closely correlated with cardiac structure and function.