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Self-assembly and drug delivery behaviors of a novel thermo-sensitive block glycopolymer
  • ISSN号:1003-3726
  • 期刊名称:《高分子通报》
  • 时间:0
  • 分类:O633[理学—高分子化学;理学—化学] TB383[一般工业技术—材料科学与工程]
  • 作者机构:[1]DSAMP Laboratory and PCFM Laboratory, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China, [2]Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China
  • 相关基金:This work was supported by the National Natural Science Foundation of China (30470476, 20676155) and Natural Science Foundation of Guangdong Province, China (06023103).
中文摘要:

(2-ethyl-2-oxazoline )(PEtOz ) 新奇的 thermo 敏感的块 glycopolymer 第一次基于 peracetylated maltoheptaose (AcMH ) 并且 poly 被综合并且由氢描绘了原子磁性的回声(1H NMR ) 光谱学和胶化浸透用色层法分离(GPC ) 分析。获得如此的块聚合物, dihydroxyl (2-ethyl-2-oxazoline ) poly, homopolymer (OH-PEtOz-OH ) 被 2-ethyl-2-oxazoline (EtOz ) 的 cationic 戒指洞聚合首先综合,然后结合了在减少的结束有一个免费氢氧根组的 peracetylated maltoheptaose (AcMH -- 哦) 从 -cyclodextrin 准备了。这被发现获得的块聚合物能进没有任何器官的溶剂,有在水的答案的不同核心壳结构的球形的微粒由它的 amphiphilic 特性触发了的 nanosize 自我装配。模型药消炎痛(IND ) 高效地被装进结果的聚合微粒,它被 1H NMR 证实系列,传播电子显微镜(TEM ) 和散布的动态光(DLS ) 技术。IND 的版本行为装载了微粒响应环境温度变化好。产生微粒可能是为药交货的一个潜在的指向的搬运人,这被建议。

英文摘要:

A novel thermo-sensitive block glycopolymer based on peracetylated maltoheptaose (AcMH) and poly(2-ethyl-2-oxazoline) (PEtOz) was synthesized for the first time and characterized by hydrogen nuclear magnetic resonance (IH NMR) spectroscopy and gel permeation chromatograph (GPC) analyses. To obtain such a block polymer, the dihydroxyl poly(2-ethyl-2-oxazoline) homopolymer (OH-PEtOz-OH) was first synthesized by cationic ring-opening polymerization of 2-ethyl-2-oxazoline (EtOz), and then coupled with the peracetylated maltoheptaose having a free hydroxyl group at the reducing end (AcMH-OH) prepared from β-cyclodextrin. It was found that the obtained block polymer could self-assemble into nanosize spherical micelles with a distinct core-shell structure in aqueous solution triggered by its amphiphilic character without any organic solvent. The model drug indomethacin (IND) was efficiently loaded into the resultant polymeric micelles, which was confirmed by ^1H NMR spectra, transmission electron microscope (TEM) and dynamic light scattering (DLS) techniques. The release behavior of IND loaded micelles was well in response to the environmental temperature change. It is suggested that the resulting micelles might be a potential targeted carder for drug delivery.

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期刊信息
  • 《高分子通报》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国化学会 中国科学院化学研究所
  • 主编:黄志镗
  • 地址:北京中关村北一街二号(北京2709信箱)
  • 邮编:100190
  • 邮箱:gfztb@iccas.ac.cn
  • 电话:010-62588926
  • 国际标准刊号:ISSN:1003-3726
  • 国内统一刊号:ISSN:11-2051/O6
  • 邮发代号:80-294
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:12665