中文摘要：

探讨了7个联萘化合物在甘氨酸型手性固定相上的拆分,考察了流动相组成、柱温等对保留及手性拆分的影响,结合计算得到的热力学参数对手性识别机理进行了探讨。联萘酚及溴代联萘酚在该固定相上得到了良好的分离,其2个醚类衍生物得到了部分拆分,而3个酯类衍生物完全无法分离。拆分过程为焓驱动,酚羟基对提高二异构体与手性固定相之间的作用差异起关键作用。

英文摘要：

Enantioseparations of seven binaphthyl compounds based on phenylglycine chiral stationary phase,Chirex 3001,were studied.The effects of mobile phase composition and the column temperature on the retention and enantioseparation were discussed.The mechanism of chiral recognition was studied using the thermodynamic parameters.It was found that binaphthol and bromosubstituted binaphthol were well enantioseparated on the Chirex 3001 stationary phase,but two ether derivatives were only partially enantioseparated and the other three ester derivatives were no fully resolved.Results also indicated that the enantioseparations of these compounds were of an enthalpy-driven type.The phenol hydroxyl group was considered to play a key role in increasing the differenc of interaction between the two isomers and the chiral stationary phase.