中文摘要：

目的：探索氨磺必利和利培酮治疗精神分裂症的效果以及安全性。方法：选取2016年4—11月本院收治的精神分裂症住院患者80例作为研究对象，将患者随机分为氨磺必利组（采用氨磺必利治疗）和利培酮组（采用利培酮治疗），对比两组患者的治疗效果。结果：两组患者治疗2、4、6周时的PANSS评分与治疗前比较，差异均有统计学意义（P〈0．05）。氨磺必利组患者治疗6周时的总有效率为87．5％，与利培酮的82．5％比较，差异无统计学意义（χ^2=0．392，P〉0．05）。氨磺必利组患者的不良反应发生率为10．0％，低于利培酮组的30．0％，差异有统计学意义（χ^2=5．000，P〈0．05）。氨磺必利组患者治疗2、4、6周时的血清催乳素水平均明显低于利培酮组，差异均有统计学意义（P〈0．05）。氨磺必利组治疗6周时的PSP评分明显高于利培酮组，差异有统计学意义（P〈0．05）。氨磺必利组患者的心理健康、社会功能评分均高于利培酮组，差异均有统计学意义（P〈0．05）。结论：氨磺必利和利培酮在治疗精神分裂症上均能取得较好的效果，氨磺必利的安全性更高，且有助于促进患者的生活质量、社会功能的提高，值得在临床上推广应用。，

英文摘要：

Objective： To explore the efficacy and safety of Amisulpride and Risperidone in the treatment of schizophrenia.Method： 80 patients with schizophrenia were randomly selected in our hospital from April 2016 to November 2016, patients were randomized into the Amisulpride group （ treated with Amisulpride ） and the Risperidone group （treated with Risperidone ）, the therapeutic effects of two groups were compared.Result： The PANSS scores of the two groups at 2, 4, 6 weeks of treatment were compared with that before treatment, the differences were statistically significant （ P〈0.05 ） .After 6 weeks of treatment, the total efficiency of Amisulpride group was 87.5%, compared with 82.5% of the Risperidone group, the difference was not statistically significant （ χ^2=0.392, P〉0.05 ） .The adverse reaction rate of the Amisulpride group was 10.0%, lower than 30.0% of the Risperidone group, the difference was statistically significant （ χ^2=5.000, P〈0.05 ） .The serum prolactin levels at 2, 4, 6 weeks of the Amisulpride group were significantly lower than those in Risperidone group, the differences were statistically significant （ P〈0.05 ） .At 6 weeks, the PSP score of Amisulpride group was significantly higher than that in Risperidone group, the difference was statistically significant （ P〈0.05 ） .The mental health, social function scores of the Amisulpride group were higher than those in Risperidone group, the differences were statistically significant （P〈0.05） .Conclusion： Amisulpride and Risperidone can achieve good curative effect in the treatment of schizophrenia, and the safety of Amisulpride will benefit more, and help to promote the quality of life of patients, improve the social function, it is worthy of clinical application.