目的:探讨中医药治疗再生障碍性贫血(AA)的用药规律。方法:应用文献检索方法检索1979—2009年在中国知网(CNKI)、维普资讯网(VIP)、万方数据知识服务平台收录的有关中医药治疗AA的文献;以含1~7味药的方剂为研究重点,分析药物归类、用药频次以及药对、常用方剂的出现频次。结果:补虚药、清热药和活血化瘀药分别占42.6%、16.0%和7.4%;黄芪、当归和熟地、枸杞子、鹿角胶用药频次位列补气药、补血药、补阴药、补阳药之首;具有清热凉血功效的生地、丹皮位居清热药之首;具有活血养血之功效的鸡血藤位于活血化瘀药之首。2味药方剂中女贞子与墨旱莲、黄芪与当归是出现频次列居前2位的药对和方剂,即二至丸和当归补血汤。3味药方剂中生脉散是出现频次最高的方剂。4味药方剂中当归与熟地、生地与丹皮、当归与川芎以及四君子汤、四物汤和犀角地黄汤是出现频次最高的药对和方剂。5~7味药方剂中黄芪和党参、生地和丹皮、丹皮和赤芍是出现频次列居前3位的药对,犀角地黄汤、六味地黄丸、四君子汤、左归饮、四物汤、金匮肾气丸为常用方剂,其中犀角地黄汤的出现频次最高。结论:以补气养血、滋阴助阳为主,兼以清热、凉血组方用药是治疗AA的基本用药规律;黄芪、当归与熟地、枸杞子、鹿角胶以及生地、丹皮、鸡血藤为治疗AA的常用药物;黄芪与党参、生地与丹皮、丹皮与赤芍、黄芪与当归为治疗AA的常用药对;犀角地黄汤、四君子汤、四物汤、六味地黄丸、左归饮、二至丸、当归补血汤为治疗AA的常用方剂。
Objective: To explore medication law for treating aplastic anemia( AA) with Chinese Medicine. Methods: The literature about traditional Chinese medicine( TCM) treating AA published at home from 1979 to 2009 in China national knowledge infrastrueture( CNKI),VIP information network and Wangfang date knowledge service platform were collected with the method of literature retrieval. The prescriptions with 1- 7 traditional Chinese drugs( TCDs) were as the research priority to analyze drugs sorts,frequency of drug application,occurrence frequency of couplet medicinals and most commonly- used prescriptions. Results:TCDs for invigorating deficiency,clearing heat,promoting blood circulation and removing blood stasis covered 42. 6%,16. 0% and7. 4% respectively. The frequency of drug application of Mongolian milkvetch root,Chinese angelica and prepared rehmannia,barbury wolfberry fruit and antler glue ranked first in the drugs for tonifying qi,tonifying blood,tonifying yin and tonifying Yang respectively. Dried rehmannia and cortex moutan with the efficiency of removing heat to cool blood,suberect spatholobus stem with the efficiency of activating blood and tonifying blood ranked first in the drugs for clearing heat,promoting blood circulation and removing blood stasis respectively. Among the prescriptions with 2 TCDs,the occurrence frequency of Glossy privet fruit and Yerbadetajo herb,Mongolian milkvetch root and Chinese angelica held first two places in the couplet medicinals and the most commonly- used prescriptions,which were named Erzhi Wan and Danggui Buxue Tang respectively. Shengmai San was the prescription with the highest occurrence frequency among the prescriptions with 3 TCDs. The couplet medicinals and commonly- used prescriptions with the highest occurrence frequency were Chinese angelica and prepared rehmannia,dried rehmannia and cortex moutan,Chinese angelica and Szechwan lovage rhizome as well as Sijunzi Tang,Siwu Tang,Xijiao Dihuang Decoction among the prescriptions with 4 TCDs. Among