中文摘要：

随着分子成像技术和各种纳米生物材料的迅速发展，医学影像技术有望对人体疾病实现从器官、组织水平到细胞、分子水平全方位、多层次在体实时观察．通过基于分子靶标的肿瘤早期诊断、革命性的肿瘤分子分型以及肿瘤边界确定和术中手术导航的全面开展，实现精准医学．超声分子影像是分子影像学的一个新的分支，在近10年发展迅速．液气相变型超声分子探针凭借其良好的穿透性以及诊疗一体化等优点，已显示出其优于传统超声分子探针的众多优势，在基础与临床应用方面展现出巨大潜力．本文对液气相变型超声分子探针的相变机制以及近几年在生物医学应用领域的研究进展进行了综述．

英文摘要：

With the rapid development of molecular imaging technology and materials science, it is very possible for the medical imaging techniques to enable the real-time and multi-modality visualization, characterization, and quantification of biologic processes taking place at the organ, tissue, cellular and molecular levels within intact living subjects. Via the comprehensive progress in terms of tumor early diagnosis based on molecular targets, a revolutionary tumor molecular classification, tumor boundary determination, and surgical navigation, the precision medicine will be achieved. Ultrasound （US） molecular imaging, which is a new branch of molecular imaging, has developed rapidly in the latest decades. The phase-transitional molecular probe has shown significantly more superiority than the traditional US contrast agents owing to its good penetration, stability and the ability for theranostical integration, which indicates a better potential in the basic researches and the clinical applications. In this paper, we reviewed the progress in the studies of the phase-transitional ultrasound molecular imaging probe and its applications in biomedicine.