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中文摘要：
应力负荷是骨质量和骨骼几何形状的主要调节因子.骨细胞信号网络通过感知骨骼力学负荷而发挥作用,是应力负荷的主要传感器.骨细胞死亡后发生骨重建,骨骼力学负荷减小或丧失.骨折后所致长期卧床、局部制动导致骨细胞凋亡和骨吸收,引起严重的骨质疏松.通过分析骨骼适应应力负荷的机制,骨细胞感受机械刺激和骨骼的力学负荷,力学负荷对骨骼的作用和应力负荷与骨重塑过程的分子调控等,可以探讨应力负荷与骨骼结构及与骨重建的关系.
英文摘要：
Mechanical loading is a major regulator of bone mass and bone geometry.The osteocytes signal network plays an important role through the mechanical load, which is considered the main sensor of loads.Bone remodeling occurs after osteocyte dies, thereby the skeletal mechanical load reduces or loses.Long-term bed rest and inactive mode caused by fracture, lead to osteocyte apoptosis and bone resorption,therefore leading to severe osteoporosis.By analyzing the mechanism of mechanical adaptation of bone, the mechanical stimulation of osteocyte and the mechanical load of bone, the relationship of mechanical load and bone structure, bone remodeling process can be investigated.
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