中文摘要：

采用亚结构拼接法,将苯氧乙酸类结构引入酰基硫脲中,设计并合成了8个新型的硫脲类化合物——N-（取代苯氧乙酰胺基）-N＇-（1-甲基环己基酰基）硫脲（5a-5h）;5a-5h在酸性条件下关环形成8个新型的含1,3,4-噻二唑的酰胺类化合物——1-甲基-N-（5-取代基-1,3,4-噻二唑-2-基）环氧甲酰胺（6a-6h）,其结构经1^H NMR和ESI-MS表征。初步的生物活性测试结果表明,在用药量为500mg·L^-1时,N-（2,4-二氯苯氧乙酰胺基）-N＇-（1-甲基环己基酰基）硫脲对粘虫的抑制率为80%。

英文摘要：

Eight novel thiourea compounds,N-（substituted-aryloxyacetyl amino）-N＇-（1-methylcyclohexylacyl） thiourea（5a - 5h）,were designed and synthesized by introducing substituted phenoxy acetic acid pharmacophore into the thiourea scaffold.Then eight novel amide compounds containing 1,3,4-thiadiazole moiety,1-methyl-N-（5-substituted-1,3,4-thiadiazol-2-yl） cyclohexanecarboxamide（6a - 6h）,were synthesized by cyclization of 5a - 5h under weak acid.The structures were characterized by1 ^H NMR and ESI-MS.The biological activities of 5a - 5h were tested.The results showed that N-{2-[2-（2,4-dichlorophenoxy） acetyl]hydrazinecarbonothioyl}-1-methylcyclohexanecarboxamide exhibited inhibiting effect against Armyworm with 80.0% death rate at 500mg·L^-1.