中文摘要：

用光谱法研究了带有吩嗪基团的酚藏花红与DNA的相互作用．研究表明，酚藏花红能嵌入到DNA骨架的碱基对之间，在实验允许的误差范围内，用不同的光谱法测得的结合常数一致，均为10^4L·mol^-1数量级，结合位点数约为7．阴离子KI的荧光猝灭实验进一步证实了酚藏花红与DNA之间的嵌入作用，该研究为以DNA为靶的药物设计提供了一种新的嵌入剂功能团．

英文摘要：

The interaction of Phenosafranine（PF）, which features a phenazinyl group, with DNA was investigated by spectroscopy. The studies indicated that PF could intercalate into the stack base pairs of DNA. Intrinsic binding constants obtained by different spectral methods were consistent within experimental errors. The binding constants are of the order of 10^4L· mol^-1 in DNA base pairs, and the estimated binding sites are about 7 in DNA base pairs. The results of the studies on fluorescence quenching by anionic quencher KI also confirmed the intercalative binding of PF with DNA. This research proposed a new intercalation functional group to DNA-targeted drug design.