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中文摘要：
肿瘤抑制基因第10号染色体缺失的磷酸酶和张力蛋白同源等位基因（PTEN）在多种类型细胞中通过抑制磷脂酰肌醇-3激酶（P13K）信号通路在细胞增殖、移行和凋亡调控中发挥重要作用。大量体内、体外实验表明，PTEN／P13K信号下调与神经元形态改变存在直接关系，并与许多神经精神疾病的发病机制相关。现就PTEN在大脑发育和神经元回路形成与维持中的作用进行综述。
英文摘要：
Phosphatase and tensin homologue deleted on chromosome 10 （PTEN） is a tumor suppressor which can inhibit proliferation and migration and control apoptosis in a number of cell types, mainly through inhibiting the phosphoinositide 3 - kinase（PI3K） signaling pathway. A number of in vitro and in vivo studies has been instrumental in uncovering a direct correlation between deregulated PTEN/PI3K signaling and changes in neuronal morphogenesis, which is likely to have profound bearings upon the pathogenesis of neurological symptoms. This review outlines recent work on the function of PTEN during the formation and maintenance of neuronal circuits in the brain.
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