中文摘要：

采用原位聚合法成功地制备出聚乳酸／聚（异丙基丙烯酰胺-co-丙烯酰胺）[P（D，L-LA）／P（NIPAM-co-AM）]温敏性核壳胶束．用SEM，TEM和AFM等方法表征了粒子的外在形貌和内部结构．DES研究结果表明，所得核壳粒子的尺寸具有温度敏感性，通过改变单体的投料比，可方便地调整胶束粒子的响应温度．对胶束粒子的染料负载行为做了初步的研究．

英文摘要：

In-situ polymerization, which had been developed in our group, was employed to prepare thermo- sensitive poly （ D, L-lactic acid ）/poly （ N-isopropyl acrylamide-co-acrylamide ） （ PLA/PNIPAM-co-AM ） coreshell micelles. The resultant micelles N100, N90 and N80 were obtained in which the mass fractions of hydrophilic AM units in the feeds were 0, 10% and 20% , respectively. SEM, TEM and AFM were used to observe the morphologies of the micelles and the results confirmed the core-shell structure. The nanoparticles show a significant size change with the variation of temperature. The diameter of N100 decreases from 207.3 nm to 140. 1 nm when temperature increases from 27 ℃ to 41 ℃. The responsive temperatures of N100, N90 and N80 were found to be 33, 41 and 56 ℃, respectively, which means that the responsive temperature of the micelles can be adjusted by changing the shell compositions. In addition, the dye-loading behavior of the nanoparticles was also studied.