中文摘要：

通过急性试验确定内皮素（Endothelin，ET）对试验肉鸡肺动脉压的升压作用及其量效关系；在肉鸡快速生长期长时间给予ET，观察试验鸡发病率变化。结果表明：（1）在25ng／kg剂量静脉给予时，可引起肉鸡肺动脉压升高并达到与发病鸡相近的水平。（2）长期给予ET后，试验组30d发病率为6．7％，44d发病率13．3％，对照组发病率为0。同时，试验组红细胞压积（PCV）、腹水心脏指数（AHI）亦显著高于对照组。此结果表明，ET-1可通过缩血管效应引起肺动脉压升高，是致发肉鸡腹水综合征的一个重要因素。

英文摘要：

To clarificate the action of ET-1 on PHS broiler, clinical PHS cases were divided into groups with age. An acute experiment was used to confirm the effect of endothelin-（ET） on experiment broiler and its relevance of effect with the dose on broiler. ET-1 had been administered into broilers for 2 weeks from 15 days to 30 days of age, Results showed. （1）The mean pulmonary artery pressure（PAPm） of broilers administered with 25 ng/kg by iv had arrived at the level of those in natural cases, （2）The incidence rates of broilers treated with 25 ng/ kg ET-1 for 2 weeks were 6, 70/00 and 13.3% respectively at the age of 30 d and 44 d. The packed cell volume and ascites heart index in test broiler were significant higher than in control. All of these demonstrated that PAPm incidence rates was obvious increased after treated with ET-1. ET-1 was proved to be a necessary factor to induce PHS.