中文摘要：

目的 研究四逆散及生慧汤拆方对神经突触可塑性的作用.方法 以SH-SY5Y细胞作为神经生长,通过CCK-8法检测细胞活力,检测不同浓度四逆散及生慧汤拆方对神经细胞增殖的影响.以PC12细胞为神经分化模型,通过细胞形态学观察及统计分析细胞突起长度及分化率,检测不同浓度四逆散及生慧汤拆方对神经细胞分化的影响.结果 四逆散对细胞增殖并无显著作用,对细胞分化具有抑制作用.生慧汤拆方4（熟地、山茱萸）具有促进细胞增殖,抑制细胞分化的作用;生慧汤拆方6（茯神、红参）具有促进细胞分化和增殖的双重作用;生慧汤拆方7（远志、石菖蒲、白芥子）具有抑制细胞增殖,促进细胞分化的作用.结论 传统改善学习记忆能力中药中的疏肝理气药物具有抑制突触可塑性的作用,祛痰益智和补气健脾类药物具有促进突触可塑性的作用.

英文摘要：

Objective To study the effects of Sini San and disassembled formulas of Shenghui Tang on synaptic plasticity. Methods SH-SYSY was taken as nerve growth model for detecting the effects of Sini San and disassembled formulas of Shenghui Tang in different doses on the proliferation of nervous cells through determining cell viability by using CCK-8 method. PC12 cells were taken as nerve differentiation model for detecting the influences of Sini San and disassembled formulas of Shenghui Tang in different doses on the differentiation of nervous cells through cell morphology observation and determination of the length and differentiation rate of synapsis by using relative statistical analysis. Results Sini San had no significant effect on cell proliferation but had inhibitory effect on cell differentiation. Among disassembled formulas of Shenghui Tang, disassembled Shenghui Tang 4 [ Shudi （Radix Rehmanniae Praeparata） and Shanzhuyu （Fructus Corni ）~ had effects of promoting proliferation and inhibiting differentiation, disassembled Shenghui Tang 6 [ Fushen （Poria cum Ligno Hospite ） and Hongshen （Radix Ginseng Rubra） ] had dual effects of promoting proliferation and differentiation, and disassembled Shenghui Tang 7 [ Yuanzhi （ Radix Polygalae）, Shichangpu （ Rhizoma Acori Tatarinowii） and Baijiezi （ Semen Sinapis Albae） ~ had effects of inhibiting proliferation and promoting differentiation. Conclusion Among traditional Chinese medicinal for improving learning and memory ability, those with the actions of soothing liver and regulating qi have effect of inhibiting synaptic plasticity, and those with the actions of dispelling phlegm and boosting intelligence, and actions of tonifying qi and fortifing spleen have the effect of promoting synaptic plasticity.