中文摘要：

目的探讨片F癌家族史对原发性肝癌患者手术后复发及生存率的影响。方法收集79例手术切除的原发性肝癌患者的家族发病情况、术后复发率1、2、5年的生存率，按有尤家族肝癌史分为2组：有家族肝癌史的原发性肝癌组为FH组，34例；无家族肝癌史的原发性肝癌绀为NH组，45例。财所有患者行术后随访，随访周期为3个月至10年，中位随访时间48．5个月，采用Kaplan—Meier牛存曲线及Log-Rank检验比较2组患者术后生存率和复发率。结果FH组34例肝癌来白33个家族，共计104例肝癌，平均3．2例／家族；单个家族中发牛3个或者3个以上盯癌的有6例（17．6％）；家族中父亲和（或）母亲患片f癌的有13例（39．4％）。FH组术后半年、1年、2年复发率为15．1％，22．3％，40．1％，与NH组的10．3％，17．4％，25．6％比较，差异均有统计学意义（分别X2=5．762，6．434，5．987，均P〈0．05）；FH组1、2、5年生存率为57％、46％、40．3％，与NH绀的85．3％、75．2％及61．5％相比较，差异有统计学意义（分别x2=8．986，9．765，7．634，均P〈0．05）。结论肝痛家族史影响HCC患者手术预后，有家族肝癌史的肝癌患者比没有家族肝癌史的肝癌患者术后复发率高，预后爱。

英文摘要：

] Objective To evaluate HCC family history on recurrence and survival of HCC patients after curative hepatectomy. Methods The family history, postoperative recurrence rate, 1, 2 and 5 year survival rate of 79 HCC patients who received surgical resection were collected. Patients were divided into two groups： 34 cases in familial aggregation HCC group （FH group ） and 45 cases in non- familial aggregation HCC group （NH group）. All these HCC patients were followed up for 3 months tol0 years after surgery, and the median follow-up period was 48.5 months. We analyzed the survival rate of HCC patients by Kaplan -Meier survival curve to compare the postoperative recurrence rate and survival rate between two groups. Results 34 cases of HCC probands came from 33 families, and there were 104 cases of HCC patients in these families, an average of 3.2 cases per family. There were 6 families in which 3 or more cases developed HCC, and there were 13 families in which father or （and） mother had HCC accounting for 39.4%. The six months, 1 year, 2 year posthepatectomy recurrence rate in FH group was 15. 1% ,22. 3% , 40. 1%, significantly higher than NH group of 10. 3%, 17.4% ,25.6% （ X2 = 5.762, 6. 434, 5. 987, P 〈 0. 05） , and 1, 2, 5 year＇s survival rate in FH group was 57% , 46% , 40. 3% , much lower than NH group of 85.3%, 75.2% and61.5% （X2 =8.986,9.765,7.634,P〈0.05）. Conclusions Family history of HCC affects the prognosis of HCC patients after surgery. Patients with HCC family history have higher postoperative recurrence rate and worse prognosis than that of patients who do not have HCC family history.