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Organocatalytically Enantioselective Approach to Polysubsti- tuted Tetrahydropyridines and Piperidines
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 时间：0
  • 分类：TQ463.4[化学工程—制药化工] O621.256.7[理学—有机化学;理学—化学]
  • 作者机构：[1]Shenyang Pharmaceutical University, 103 Wenhua Lu, Shenyang, Liaoning 110016, China, [2]State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
  • 相关基金：Project supported by the National Natural Science Foundation of China （No. 20921091）.
作者： Yu, Fang[1], Zhang, Xiaojing[1], Jiang, Yongwen[2]
关键词： 对映选择性, MICHAEL加成, 不饱和酯, 缩醛, 反应, 环化, 伯胺, 还原, organocatalysis, Michael addition, reductive amination, substituted piperidine, tetrahydropyridine
中文摘要：

方便的 A 并且高度，为 functionalized 1,2,3,4,5-pentasubstituted tetrahydropyridines 和哌啶的汇编的 enantioselective 方法被开发。这个方法依靠准备要求的 enantiopure 经由醛和 -keto-,-unsaturated 酉旨的 organocatalyzed 迈克尔增加 / 环合串联反应的周期的半缩荃，和有主要的胺的随后的减少的胺化作用 / 冷凝作用。

英文摘要：

A convenient and highly enanfioselecfive method for assembly of functionalized 1,2,3,4,5-pentasubstituted tetrahydropyridines and piperidines was developed. This method relies on preparing the required enantiopure cyclic semi-acetals via an organocatalyzed Michael addition/cyclization cascade reaction of aldehydes and a-keto-α,β- unsaturated esters, and subsequent reductive amination/condensation with primary amines.

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期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175