中文摘要：

为探讨蔓菁多糖对小鼠抗高原缺氧的作用,将小鼠随机分为6组,正常对照组、模型对照组、阳性对照组（诺迪康胶囊）及蔓菁多糖低、中、高剂量组（各组按照0.5、1.0、2.0 g/kg.bw.d剂量灌胃给药）,采用低压氧舱模拟高原急性低压缺氧动物模型,观察小鼠海马区脑神经形态,测定小鼠脑组织和血清中丙二醛（MDA）、超氧化物歧化酶（SOD）活性.实验结果显示,蔓菁多糖高剂量组可明显减轻小鼠海马区神经元损伤,降低脑组织和血清中MDA含量（P＜0.05）,提高SOD活性（P＜0.05）.表明蔓菁多糖对小鼠高原急性缺氧脑损伤具有保护作用,这可能与其抗氧化活性有关.

英文摘要：

Abstract： This paper investigates the anti-hypoxia effect of polysaccharide from Brassica rapaL, on mice with acute high-altitude exposure. Mice are divided randomly into six groups, which are normal control group, model control group, positive control group（ Nuodikang capsules）, and polysaccharide low, medium and high dose groups（0.5,1.0,2.0 g/kg. bw. d respectively）. This paper uses hypobaric chamber to simulate the models of animals with acute high-altitude hypobaric hypoxia. The neuronal morphology in the hipix）campus of mice is observed.The content of malondialdehyde（MDA） and the activity of superoxide dismutase（SOD） in mouse brain tissue and senma are measured. The experimental results show that the po- lysaccharide can significantly alleviate the neuronal damage in the hippocampus of mice, and reduces the content of MDA（P 〈 0.05） and increases the activity of SOD（P 〈 0.05） in brain tissue and serum. We conclude that the polysaccharide from Brassica rapaL, has a protective effect on cerebral injury of mice with acute high-altitude hypoxia, which may be related to the antioxidant activity.