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中文摘要：
前列腺素E2（PGE2）是一种重要的花生四烯酸代谢产物,通过与4种G蛋白偶联的受体（EP1、EP2、EP3、EP4）作用而广泛参与多种生理和病理生理活动。研究表明4种EP受体在肾脏和血管系统中均有分布,PGE2通过作用于EP受体而具有降低血压及调节血压稳态平衡的作用。此外,PGE2通过EP受体在盐敏感性高血压、肾性高血压、心肌肥大等血压相关疾病中也发挥着重要的作用。
英文摘要：
Prostaglandin E2（PGE2）is one of the major metabolic products of arachidonic acid.PGE2 plays important roles in various important physiological processes by binding to its G protein-coupled receptors designated EP1,EP2,EP3,and EP4,respectively.EP receptors are highly expressed in the kidney and cardiovascular system,and PGE2-mediated activation of EP receptors plays important roles in the regulation of blood pressure.The abnormal expression of EP receptors in the kidney and cardiovascular system is associated with some blood pressure disease such as salt-sensitive hypertension,renal hypertension,and myocardial hypertrophy.
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