中文摘要：

杀结核菌素是一个吡咯[2，3-d]嘧啶核苷天然产物，具有显著的抗血吸虫感染、抗菌和抗肿瘤活性．报道了以微波促进的Vorbruggen糖基化反应为关键步骤，以6-氯-7-溴·吡咯[2，3-d]嘧啶和1-O-乙酰基-2，3，5-O-三苯甲酰基-β-D-呋喃核糖为原料，经过3步反应以74％的总收率完成了杀结核菌素的全合成．同时研究了以全氟丁基磺酸钾、三甲基氯硅烷和硅基化试剂[六甲基二硅胺烷或者N,O-双（三甲基硅基）乙酰胺]在微波加热下一锅法合成7-去氮嘌呤核苷的方法．

英文摘要：

Tubercidin is a naturally occurring pyrrolo[2,3-d]pyrimidine nucleoside with significantly biological activities, such as anti-schistosomal, antibacterial and antitumor. An improved total synthesis of tubercidin is reported using microwave promoted Vorbriiggen glycosylation as the key step. Thus, tubercidin was synthesized in 3 steps with 74% overal yield using 6-chloro-7-bromo-pyrrolo[2,3-d]pyrimidine and 1-O-acetyl-2,3,5-O-tribenzoyl-fl-D-ribose as starting materials. The applica- tion of micromave irridated one-pot reaction is also reported in the synthesis of 7-deazapurine nucleosides using potassium nonafluoro-l-butanesulfonate, trimethylsilyl chloride and silylation reagent [hexamethyldisilazane or N,O-bis（trimethylsilyl）acetamide].