中文摘要：

脂筏是膜脂双层内富含特殊脂质（胆固醇和鞘脂）和蛋白质的微区,脂筏作为独特的信号转导平台不仅可以为内部分子提供一个＂交流＂的环境,也有助于加快信号传递。Ca2＋作为重要的信号分子,参与调控细胞许多生理功能。细胞内Ca2＋浓度受各种信号分子,钙泵和钙池操纵的Ca2＋内流等多种因素调节。最新研究发现：瞬时受体电位通道的一些成员、基质相互作用分子1以及Orai1在钙池操纵的钙通道介导的Ca2＋内流过程中发挥着重要的作用。大量Ca2＋通道和蛋白质（包括钙信号途径的关键蛋白）在脂筏微区集聚,脂筏功能越来越受到人们的关注。

英文摘要：

Lipid rafts,a lipid bilayer membrane,are cholesterol and sphingolipid-enriched microdomains that function is as unique signal transduction platforms.Lipid rafts not only provide a favorable environment for intra-molecular cross-talk but also provide a help to speed up signal transmission.As an important signaling molecule calcium,it is involved in the regulation of multiple physiological cell functions.Intracellular calcium concentration（i） is regulated by a various signaling molecules,such as calcium pumps,store operated Ca2＋ entry（SOCE） and so on.Recent advances in this field suggest that some members of transient receptor potential canonicals（TRPCs）,orai1 and stromal interaction molecule 1（STIM1） play an important role in the process of SOCC-mediated calcium influx.Recent studies have demonstrated that a large number of Ca2＋ channels and calcium signaling proteins are localized in lipid rafts microdomains,which is attracted more and more attentions.