DYRK (双特性的 tyrosine-phosphorylation-regulated kinase ) 的蛋白质家庭被一个保存 kinase 领域和 N 终端 DH 盒子的存在描绘。DYRK2 涉及调整关键发展、细胞的过程,例如神经发生,房间增长,胞质分裂,和细胞的区别。此处,我们报导在 zebrafish 发现的 DYRK2 的 ortholog 与人,老鼠,和小鸡的分享大约 70% 身份。RT-PCR 证明 DYRK2 被表示似母亲并且 zygotically。在原处,杂交结果证明 DYRK2 在将发展成肌肉的体节房间被表示。我们的结果为在 zebrafish 肌肉开发调查 DYRK2 的 in-vivo 函数提供初步的证据。关键词 zebrafish - DYRK2 -在原处杂交-肌肉开发由海洋的药(中国的海洋大学)的关键实验室的开的研究资金节目支持了,到X.的教育部的资助黝黑, KLMD ( OUC ) 200609 ,并且中国(号码 30970423 )的国家自然科学基金会
Proteins of the DYRK(dual-specificity tyrosine-phosphorylation-regulated kinase) family are characterized by the presence of a conserved kinase domain and N-terminal DH box.DYRK2 is involved in regulating key developmental and cellular processes,such as neurogenesis,cell proliferation,cytokinesis,and cellular differentiation.Herein,we report that the ortholog of DYRK2 found in zebrafish shares about 70% identity with that of human,mouse,and chick.RT-PCR showed that DYRK2 is expressed maternally and zygotically.In-situ hybridization results show that DYRK2 is expressed in somite cells that will develop into muscles.Our results provide preliminary evidence for investigating the in-vivo function of DYRK2 in zebrafish muscle development.