中文摘要：

阿尔茨海默病（AD）是最常见的老年神经退行性疾病之一。研究发现，免疫系统的功能状态与AD的发病密切相关，而其中炎症反应及促炎细胞因子起着关键性的作用。AD患者脑内可见小胶质细胞与星形胶质细胞的活化，其活化可产生神经保护作用，但诱发致炎因子分泌过度反而加剧了疾病的进程。

英文摘要：

Alzheimer＇s disease （AD）is the most common neurodegenerative disease in elderly. Previous study found that the onset of AD was closely associated with the functional status of the immune system,in which inflammation and proinflammatory cytokines play key roles. Microglia and astrocyte are activated in the brain of AD patients. In addition of neuroprotcctive effect produced after activation of microglia and astrocyte, proinflammatory cytokines excessive release could also been found, which probably exacerbated the disease process.