采用改性Hummers法制备了氧化石墨烯,并探索了其在生物医学方面作为纳米药物载体的应用。通过超声、振荡等方法制备了氧化石墨烯-盐酸阿霉素(GO-DXR),采用高分辨透射电镜(HRTEM)、傅里叶变换红外光谱(FT-IR)、紫外-可见分光光谱(UV-Vis)等测试方法对GO负载DXR前后的形貌和结构进行了研究。DXR在GO上的负载量高达4.6mg/mg,DXR的释放量可通过pH值控制,说明GO与DXR之间依靠氢键作用结合。
We synthesize nano-graphene oxide with modified hummers and explore the biological applications of nano-graphene oxide as a nanocarrier.A novel graphene oxide-doxorubicin hydrochloride was prepared via a method of sonication and oscillation,the loading and release behaviors of DXR on GO were investigated by high-resolution transmission electron microscopy(HRTEM),Fourier transform infrared spectroscopy and UV-Vis spectrophotometer.The loading capacity was up to 4.6mg/mg,the release of DXR indicated strong pH dependence and imply hydrogen-bonding interaction between GO and DXR.