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Synthesis and Properties of a Biodegradable Dendritic Magnetic Resonance Imaging Contrast Agent
  • ISSN号：1001-604X
  • 期刊名称：Chinese Journal of Chemistry
  • 时间：2014.1
  • 页码：91-96
  • 分类：TP18[自动化与计算机技术—控制科学与工程;自动化与计算机技术—控制理论与控制工程]
  • 作者机构：[1]Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China, [2]Department of Radiology, Sir Run Run Shaw Hospital (SRRSH) of School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310027, China, Email: Jianbin Tang (jianbin@zju.edu.cn), Hongjie Hu (hongjiehu@zju.edu.cn)[*] Jianbin Tang, Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China, Tel.: 0086-0571-87953925, Fax: 0086-0571-87953925Hongjie Hu, Department of Radiology, Sir Run Run Shaw Hospital (SRRSH) of School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310027, China
  • 相关基金：This work was financially supported by the National Natural Science Foundation of China (Nos.20904046,21174128,and 21090352) and the Qianjiang Talent Program of Zhejiang Province of China (No.2010R10050).
  • 相关项目：拓扑高分子的精密合成
作者： Li, Tingting|Qian, Yue|Ye, Mingzhou|Tang, Jianbin|Hu, Hongjie|Shen, Youqing|
关键词： DENDRIMER, magnetic, RESONANCE, IMAGING, BIODEGRADABLE, tumor, IMAGING, dendrimer, magnetic resonance imaging, biodegradable, tumor imaging
中文摘要：

新奇可被细菌破坏的树枝状的对比代理人(DCA ) 基于聚酯 dendrimers 被综合并且描绘。DCA 在生理的 pH 很快在酸的 pH，而是 hydrolyzed 是稳定的，它象小分子 CA 的一样使 DCA 的长期的 Gd3+ 保留变为低。他们 10.2 ～ 17.5 L 祬的纵的 relaxivities？？

英文摘要：

Novel biodegradable dendritic contrast agents (DCAs) based on polyester dendrimers were synthesized and characterized.The DCAs were stable at acidic pH,but hydrolyzed rapidly at physiological pH,which rendered the DCA's long-term Gd3+ retention as low as that of small molecule CAs.Their longitudinal relaxivities of 10.2 to 17.5 L·mmol-1·s-1 were about 2.4 to 4.1 times higher than that of DTPA-Gd,indicating their superior contrast-enhancing capability to the clinically used contrast agent.The in vivo MRI study suggested that the DCA at lower generation (G2-DTPA-Gd) could effectively enhance the MRI of tumor,while the one at higher generation (G5-DTPA-Gd) showed more potential in liver imaging.

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期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175