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nesfatin-1与2型糖尿病共病抑郁症的相关性研究

ISSN号：1673-2952
期刊名称：《国际精神病学杂志》
时间：0
分类：R749.4[医药卫生—神经病学与精神病学;医药卫生—临床医学]
作者机构：[1]武汉大学人民医院精神卫生中心,武汉430060, [2]芜湖市第二人民医院检验科, [3]芜湖市第二人民医院临床心理科
相关基金：国家科技部十二·五科技支撑计划项目（2012BAI01B05）; 国家高技术研究发展计划（863计划）（2014AA022304）

作者：王高华[1], 魏艳艳[1], 王惠玲[1], 肖敏敏[2], 桂瑰[1], 李江波[3]

关键词： NESFATIN-1, 2型糖尿病, 抑郁症, Nesfatin-1, Type 2 diabetes mellitus, Depression

中文摘要：

目的探讨nesfatin-1与2型糖尿病共病抑郁症的相关性。方法选取2型糖尿病（T2DM）患者77例,根据抑郁症诊断标准分为T2DM共病抑郁症组25例（DDM组）、T2DM非抑郁症组52例（NDDM组）;以年龄、性别相匹配的30例健康体检者为正常对照组（NC组）。用汉密尔顿抑郁量表（HAMD）测量,并检测血浆nesfatin-1、空腹血糖（FPG）、血脂、空腹胰岛素（FINS）等水平。比较三组nesfatin-1水平变化,分析其与HAMD分数及其他指标的相关性。结果 DDM组nesfatin-1水平明显高于NDDM组及NC组（P〈0.01）。T2DM患者（77例）nesfatin-1水平与HAMD分数、C肽、甘油三酯（TG）呈显著正相关（P〈0.05）。回归分析示HAMD分数、TG和低密度脂蛋白-胆固醇（LDL-C）是影响nesfatin-1水平的独立相关因素（P〈0.05）;nesfatin-1与DDM密切相关（OR=1.140,P〈0.01）。结论共病抑郁症的T2DM患者血浆nesfatin-1水平较非抑郁症组显著升高,其与T2DM患者的抑郁程度相关,其改变可能在DDM发生发展中发挥一定作用。

英文摘要：

Objective To research the correlation between nesfatin- 1 and T2 DM complicated with depression. Methods 77 T2 DM patients were recruited. Based on ICD- 10 diagnostic criteria for depression,the patients were divided into depression with DM group（ DDM group,n = 25） and non- depression with DM group（ NDDM group,n = 52）. 30 healthy volunteers were recruited as normal control group（ NC group）. All subjects were assessed with HAMD. Fasting plasma nesfatin- 1,FPG,blood lipid profiles and FINS were detected. The nesfatin- 1 levels were compared among three groups. Results The nesfatin- 1 levels in DDM group were higher than that in NDDM group and NC group（ P〈0. 01）. In all T2 DM patients,nesfatin- 1 was positively correlated with HAMD scores,C- P,and TG levels（ P〈0. 05）. Regression analysis showed that HAMD scores,TG and LDL- C were associated with nesfatin- 1（ P〈0. 05）,nesfatin- 1 was significantly associated with DDM（ OR = 1. 140,P〈0. 01）.Conclusion The nesfatin- 1 level was elevated in T2 DM patients complicated with depression,it was related with the severity of depression. Nesfatin- 1 may partially contribute to the pathogenesis of DDM.

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