中文摘要：

目的研究淫羊藿经羊脂油炮制后对黄酮类成分生物利用度的影响。方法采用药理效应法与血药浓度法分别测定淫羊藿总黄酮与淫羊藿苷、宝藿苷Ⅰ的生物利用度。结果淫羊藿黄酮在羊脂油的作用下自组装形成胶束后，淫羊藿总黄酮、淫羊藿苷和宝藿苷Ⅰ与原形药物相比，ρmax分别提高了77．94％、38．99％和49．90％，AUC0-t分别提高了95．19％、37．76％和43．49％，AUC0-∞分别提高了119．35％、35．37％和46．26％。各药动学参数显示在炮制辅料羊脂油的作用下，淫羊藿活性黄酮自组装形成胶柬后，生物利用度显著提高。结论炮制辅料羊脂油提高了淫羊藿黄酮生物利用度，促进了其在体内的吸收。

英文摘要：

OBJECTIVE To study the influence of bioavailability of Epimedium flavonoids after processing by suet oil. METHODS Pharmacokinetics parameters of rats Epimedium flavonoids and ieariin and baohuoside Ⅰ was determining by the method of pharmacology effect and plasma concentration method. RESULTS The concentration of the Epimedium flavonoids, icariin and baohuoside Ⅰ in micelles groups were higher than that of the active pharmaceutical ingredient（API）. ρmax were increased by 77. 94%, 38. 99% and 49. 90% ; AUC0-ε increased by 95. 19%, 37. 76% and 43. 49% ; AUC0-∞ increased by 119. 35%, 35. 37% and 46. 26% on Epimedium flavonoids, icariin and baohuoside Ⅰ group. CONCLUSION Suet oil improved the bioavailability of Epimedium flavonoids and promoted its absorption.