中文摘要：

黄曲霉毒素生物合成调控机制的研究,对于理解真菌次级代谢物生物合成的调控机制及发展真菌毒素控制将起到重要的作用。真菌基因组学及其他组学技术的快速发展为我们挖掘基因组信息、获取基因表达谱继而为黄曲霉毒素生物合成调控网络及其他真菌次级代谢机制的研究提供基础。真菌次级代谢基因的表达需要不同类型的转录因子进行调控,包括通路特异性转录因子、全局性转录因子及应答各种环境信号的广泛转录因子等,对这些转录因子功能的研究加快了我们对黄曲霉毒素生物合成代谢调控机制的认识。本文主要综述了利用基因组信息对黄曲霉毒素生物合成代谢调控机制中的各类转录调控因子研究现状,并对本实验室多年来在黄曲霉毒素生物合成调控机制方面的研究进行了介绍。

英文摘要：

The study of aflatoxin biosynthesis regulatory mechanism is significant to understand the secondary mechanism in fungi and to control mycotoxins. Rapid development of fungal genomics and other omics empowers us for genome mining,and the acquisition of gene expression profiling that could provide basis for research of aflatoxin biosynthesis regulatory network and other secondary metabolisms in fungi. The expression of fungal secondary metabolism genes is regulated by different types of transcription factors including specific pathway transcription factors,global transcription factors,and various transcription factors in response to different environment impact. Researches on these transcription factors could help us to gain more comprehensive insights into aflatoxin biosynthesis regulatory network. In this paper,the researches on various transcription factors involved in aflatoxin biosynthesis are reviewed,and studies on the regulatory mechanism of aflatoxin biosynthesis made in our lab are introduced as well.