中文摘要：

目的探讨血管包绕肿瘤细胞团（VETC）结构在肝癌、结直肠癌组织及其肝内转移瘤中的表达。 方法收集50例肝癌伴肝内转移患者的组织标本，40例结直肠癌伴肝内转移患者的组织标本，使用免疫组织化学法检测各病例原发肿瘤和肝内转移瘤中VETC结构。结果共收集肝癌样本50例，其中34例原发肝癌组织为VETC阴性，阴性率为68.00%，34例原发肝癌组织阴性者其肝内转移瘤亦为VETC阴性；16例原发肝癌组织为VETC阳性，阳性率为32.00%。在此16例中，肝内转移瘤VETC阳性7例，占原发肿瘤VETC阳性病例数的43.75%，阴性9例。收集结直肠癌样本40例，其原发肿瘤及其肝内转移瘤均为VETC阴性。 结论 VETC结构是肝癌组织中常见现象，而罕见于结直肠癌及其肝转移瘤，VETC结构是肝癌肝内转移的潜在途径之一。

英文摘要：

Objective To study the expression of vessels-encapsulated tumor cluster （VETC） structure in hepatocellular carcinoma （HCC） and colorectal cancer, together with their hepatic metastases.Methods Fifty cases of HCC and 40 cases of colorectal cancer tissues, together with their metastatic tissues were collected. Immunohistochemistry was used to detect the expression of VETC structure in HCC and colorectal cancer, as well as their hepatic metastases.Results In the 50 cases of primary HCC tissues, 34 cases were VETC negative （68.00%）, and the remaining 16 cases were VETC positive （32.00%）. The hepatic metastases of all the VETC-negative primary HCC tissues were VETC negative. Nine cases of the hepatic metastases in VETC-positive group were VETC negative, while the ohter 7 cases were VETC negative （43.75%）. None of the colorectal cancer cases and their hepatic metastases was VETC positive.Conclusion VETC structure is frequently found in HCC, but rarely seen in colorectal cancer. VETC structure may be a potential pathway for liver metastasis.