Highly Enantioselective Michael Addition of Ketone to Alkylidene Malonates Catalyzed by Binaphthyl Sulfonimides in Water
- ISSN号:1001-604X
- 期刊名称:《中国化学:英文版》
- 时间:0
- 分类:O623.413[理学—有机化学;理学—化学] O621.256.7[理学—有机化学;理学—化学]
- 作者机构:[1]School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, China
- 相关基金:Acknowledgment We are grateful for financial support from the National Natural Science Foundation of China (No. 21072020), the Science and Technology Innovation Program of Beijing Institute of Technology (No. 2011CX01008) and the Development Program for Distinguished Young and Middle-aged Teachers of Beijing Institute of Technology.
关键词:
非对映选择性, Michael加成, 丙二酸酯, 酰亚胺, 催化, 联萘, 水作, 迈克尔加成, asymmetric catalysis, organocatalysis, Michael addition, malonates, sulfonimides
中文摘要:
Binaphthyl sulfonimides 被开发了催化酉同类的不对称的迈克尔增加到 alkylidene malonates ,负担得起相应迈克尔产品在对高收益(多达98%)与好对优秀 diastereoselectivity 好(依赖 99:1 医生)并且在把环境地良性的水用作溶剂的温和条件下面的 enantioselectivity (多达92% ee )。
英文摘要:
Binaphthyl sulfonimides have been developed to catalyze the asymmetric Michael addition of ketone to alky- lidene malonates, affording the corresponding Michael products in good to high yields (up to 98%) with good to excellent diastereoselectivity (up to 99 ; 1 dr) and enantioselectivity (up to 92% ee) under mild conditions using environmentally benign water as the solvent.