中文摘要：

瞬时受体电位（transiem receptor potential，TRP）超家族是一组非选择性阳离子通道，分为7个亚家族。TRPM亚家族包括8个不同的成员，TRPM1～8。TRPM2广泛表达于可兴奋细胞和非兴奋性细胞，形成Ca^2＋通透性阳离子通道，并发挥不同的细胞功能。TRPM2通道可被ADP一核糖（ADPR）、Ca^2＋、H2O2以及其他活性氧（ROS）所激活。现已证明，TRPM2作为氧化应激传感器，介导了氧化应激引起的细胞内Ca^2＋浓度升高，并参与多种细胞的生理／病理过程。丰富的证据表明，TRPM2可作为氧化应激相关疾病的一个潜在的治疗靶点。本文对以上方面的研究进展做一综述。

英文摘要：

Abstract： Transient receptor potential （TRP） superfamily is a superfamily of cation channels that can be divided into seven subfamilies. TRPM2 is the second member of the TRPM subfamily, which includes eight members, namely TRPM1-8. TRPM2 is widely expressed in excitable and non-excitable cells, where it forms a Ca^2＋-permeable cation channel and performs diverse cellular functions. TRPM2 channels are activated by ADP-ribose （ADPR）, Ca^2＋, H2O2 and other reactive oxygen species （ROS）. It is established that TRPM2 serves as a cellular sensor for oxidative stress, mediating oxidative stress-induced [Ca^2＋] increase and con- tributing to pathological processes in many cell types. Accumulating evidence has indicated that TRPM2 is a potential therapeutic tar- get for oxidative stress-related diseases. This review will highlight recent progress in this field.