目的研究采用电阻抗成像技术实现一种可早期检测持续性或迟发性颅内出血设备的可行性。方法实现了可工作于(1~190)kHz、测量精度优于0.04%、成像速度可达1.25帧/s以上的电阻抗断层成像系统。在此基础上,在8只重(10.00±0.76)kg的小猪颅内分别注入2ml抗凝血以观察成像结果,同时还分别观察了4例注入2ml生理盐水和4例注入2ml蒸馏水时相应区域电阻率的变化情况。结果注入生理盐水后,目标区域的电阻率降低,而注入蒸馏水后目标区域的电阻率升高。除2例无效实验外,注血实验中有3例因血液被注入侧脑室而导致目标区域电阻率上升,另有3例电阻率降低。结论采用电阻抗成像技术对持续性或迟发性颅内出血病人进行早期检测是可行的。
Objective To study the feasibility of electrical impedance imaging technique used as an early diagnosing device for continuous or delayed intracranial hemorrhage. Methods An electrical impedance tomography system working at (1-190) kHz was developed. The measuring precision is better than 0.04% and the imaging speed is faster than 1.25 frames/s. Experiments were done by using this system, in 8 piglets of (10.00 +0.76)kg. Intracranial injection of 2 ml anticoagulant blood was given to each animal to observe the imaging results. After that, Intracranial injection of 2 ml 0.9% saline solutions was given to 4 pigs, and Intracranial injection of 2 ml distilled water was given to the other 4 pigs. Results Resistivity in the target area decreased after injection of saline, but increased after injection of the distilled water. For the blood injections, the resistivity increased in 3 pigs as the blood was proved to be injected into the lateral ventricle, and decreased in 3 out of the other 4 pigs after the injection. It was considered as no effect in the 2 remainders, Conclusion Electrical impedance imaging technique can be used as a method of early diagnosis of continuous or delayed intracranial hemorrhage.