中文摘要：

嘧啶酮及其官能化衍生物常具有重要生理活性，因此该类化合物的合成受到了众多化学家的关注．本工作以三氯化铁催化芳醛、脲（硫脲）和环戊酮的“一锅化”Biginelli—type缩合反应，在无溶剂、无保护的条件下合成了一系列芳亚甲基稠环嘧啶酮化合物．该方法所用催化剂经济易得，且催化剂用量较少，反应条件温和，产率较高．

英文摘要：

Pyrimidinone and its functionalized derivatives are known to possess a broad-spectrum of biological activities. This paper described an efficient method for the synthesis of pyrimidinones via ferric chloride catalyzed Biginelli-type condensation of aromatic aldehyde, cyclopentanone, and urea or thiourea. The reactions produce a series of arylidene heterobicy- clic pyrimidinones in moderate to excellent yields under solvent-free conditions.