中文摘要：

目的研究红背叶根拮抗酒精性肝纤维化大鼠模型的作用机理。方法制备酒精性肝纤维化大鼠模型，观察红背叶根对该模型动物血清中转化生长因子β1、基质金属蛋白酶组织抑制因子1的影响及透明质酸酶、层粘连蛋白、Ⅲ型前胶原、Ⅳ型胶原、谷丙转氨酶（ALT）、谷草转氨酶的变化。结果红背叶根组血清中的以上8项指标与模型组相比显著减少。结论红背叶根抗肝纤维化，可能是通过对转化生长因子β1、基质金属蛋白酶组织抑制因子1表达的抑制。

英文摘要：

Objective To observe the therapeutic effect of Hongbeiyegen [the root ofAlchornea trewioides （Benth.） Muell. -Arg.] on alcohol-induced liver fibrosis （AF） in rats and explore its mechanism. Methods In rats with AF, the serum levels of transforming growth factor β1 （TGFβ1） and tissue inhibitor ofmetalloproteinase-1 （TIMP-1） were detected along with examination of the changes in serum hyaluronic acid （HA）, laminin （LN）, procolagen type Ⅲ （PC Ⅲ）, collagen type Ⅳ （CⅣ）, glutamic-pyruvic transaminase （ALT） and glutamic-oxalacetic transaminase （AST） levels. Results Compared with the control group, Hongbeiyegen could significantly reduce the levels of TGFβ1, TIMP-1, HA, LN, PCⅢ, CⅣ, ALT and AST in rats with AF. Conclusion Hongbeiyegen can relieve and ameliorate liver fibrosis possibly by inhibiting the expression of TGFβ1 and TIMP-1.