欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
Th22细胞是最近发现的CD4＋T细胞功能亚群,表达CCR6、CCR4和CCR10,且分泌IL-22和TNF-α,不分泌IFN-γ、IL-4、IL-17,是独立于Th1、Th2和Th17的细胞亚群。Th22细胞主要参与皮肤的自稳调节和病理状态,可以调控皮肤的固有免疫反应、防御功能及表皮损伤后的修复功能,在炎症性皮肤病的病理生理机制中发挥重要作用。此外,Th22细胞也参与了炎症性肠病、类风湿关节炎、肝炎、试验性自身免疫性心肌炎等炎症免疫性疾病的病理过程。本文对Th22细胞其细胞因子IL-22在炎症免疫性疾病中作用的研究进展做一综述。
英文摘要：
Th22 cells are recently described as one of the inflammatory CD4＋ T cells that express CCR6, CCR4, and CCR10. Th22 cells, separated clearly from those of Thl, Th2, and Thl7 cells, can produce IL-22, TNF- α, but do not express IL-17A, IL-4 or IFN-γ. Th22 cells may present within the epidermal layer in inflammatory skin diseases, which related to orchestrating innate immune responses, regulating keratinocyte defense mechanisms and enhancing epidermal wound healing. Furthermore, Th22 plays an important role in the pathogenesis of inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, hepatitis, and experimental autoimmune encephalomyelitis. This article reviews the role of Th22 cells and its cytokine IL-22 in inflammatory immunity diseases.
同期刊论文项目
同项目期刊论文
A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II coll
Clinical application and evaluation of anti-TNF-alpha agents for the treatment of rheumatoid arthrit
BAFF/SAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-m
A standardized extract from Paeonia lactiflora and Astragalus membranaceus attenuates liver fibrosis
The Roles of B Cells and Their Interactions with Fibroblast-Like Synoviocytes in the Pathogenesis of
The expression change of beta-arrestins in fibroblast-like synoviocytes from rats with collagen-indu
Effect of rhTACI-Ig fusion protein on antigen-specific T cell responses from keyhole limpet haemocya
TACI-Ig induces immune balance of Th cells in MLN via BLyS/APRIL-receptors signaling in rats with ad
Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymp
Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes funct
Prostanoid EP1 receptor as the target of (-)-epigallocatechin-3-gallate in suppressing hepatocellula
Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blo
Paeoniflorin inhibits proliferation of fibroblast-like synoviocytes through suppressing G-protein-co
Combined use of etanercept and MTX restores CD4(+)/CD8 (+) ratio and Tregs in spleen and thymus in c
Involvement of the prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cell apoptosi
Selective alpha(1B)- and alpha(1D)-adrenoceptor antagonists suppress noradrenaline-induced activatio
IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma ce
Effect of bone marrow-derived CD11bF4/80 immature dendritic cells on the balance between pro-inflamm
4-Amino-2-trifluoromethyl-phenyl retinate inhibits the migration of BGC-823 human gastric cancer cel
Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-ind
Ginsenoside metabolite compound K attenuates inflammatory responses of adjuvant-induced arthritis ra
Ginsenoside Metabolite Compound K Alleviates Adjuvant-Induced Arthritis by Suppressing T Cell Activa
Similar survival, but better quality of life after myeloablative transplantation using unrelated cor
ACETYLSALICYLIC ACID ENHANCES THE ANTI-INFLAMMATORY EFFECT OF FLUOXETINE THROUGH INHIBITION OF NF-ka
Dendritic cells with an increased PD-L1 by TGF-beta induce T cell anergy for the cytotoxicity of hep
The renoprotective effects of berberine via the EP4-G alpha s-cAMP signaling pathway in different st
Bone marrow CD11b(+)F4/80(+) dendritic cells ameliorate collagen-induced arthritis through modulatin
Etanercept attenuates collagen- induced arthritis by modulating the association between BAFFR expres
Etanercept attenuates collagen-induced arthritis by modulating the association between BAFFR express
Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK path
期刊信息
位置：