中文摘要：

目的：观察针刺对家兔阳离子化牛血清白蛋白（C-BSA）肾炎模型的影响，探讨针刺治疗肾炎的作用机制。方法：将50只家兔随机分成5组：空白组、模型组、美托洛尔组、厄贝沙坦组、针刺组，每组10只。通过耳缘静脉注射C-BSA进行造模。美托洛尔组及厄贝沙坦组分别给予美托洛尔和厄贝沙坦药物灌胃治疗；针刺组选取“风门”“肾俞”穴进行针刺治疗；空白组与模型组不予治疗。观察各组治疗3周、6周、8周时家兔血压、心率、血浆去甲肾上腺素含量、肌酐、尿素氮、24h尿蛋白的变化。结果：造模后，模型组肌酐（194．30±20．09）μmol／L、尿素氮（9．19±0．66）mmol／L及24h尿蛋白（277．70±20．09）mg／24h较空白组肌酐（66．03±4．76）μmol／L、尿素氮（4．11±0．71）mmol／L、24h尿蛋白（14．28±1．47）mg／24h均显著升高（均P〈0．01）；病理切片示肾小球呈弥漫性系膜增生，系膜细胞明显增多。针刺组治疗3周时不仅可明显降低肌酐（99．82±9．29）μmol／L、尿素氮（6．32±0．75）mmol／L及24h尿蛋白（189．67±15．45）μg／24h等指标，而且对血压、心率、血浆去甲肾上腺素含量的降低较其他治疗组更为明显（P〈0．05，P〈0．01）。结论：针刺可明显改善肾炎模型兔肾脏功能，降低24h尿蛋白，其作用机制可能与针刺降低交感神经兴奋性,减轻C-BSA肾炎模型兔的肾脏病理改变有关。

英文摘要：

Objective To observe the effect of acupuncture on eationized bovine serum albumin（C-BSA） nephri tis model in rabbits and to explore its mechanism. Methods Fifty rabbits were randomly divided into a blank group, a model group, a metoprolol group, a irbesartan group and an acupuncture group, 10 rabbits in each group. The model was established by ear vein intravenous injection with C-BSA. The positive control groups were treated by intragastric administrated with metoprolol and irbesartan, respectively. The acupuncture group was treated by acupuncture at＂Fengmen＂ （BL 12） and＂Shenshu＂ （BL 23）. No interventions were added on the blank group and the model group. The changes of blood pressure （BP）, heart rate （HR）, plasma norepinephrine （NE）, serum creatinine （Scr）, blood urea nitrogen （BUN） and 24 hours urine protein （24 h UP） in rabbits at the time points of 3rd, 6th and 8th week of treatment were observed. Results After the model was established, the Ser of （194.30±20. 09） μmol/L, BUN of （9. 19±0.66） mmol/L and 24 h UP of （277.70±20.09） mg/24 h in the mo del group were all higher than the Scr of （66.03±4.76）μmol/L, BUN of （4.11±0.71） mmol/L and 24 h UP of （14.28±1.47） mg/24 h in the blank group （all P〈0.01 ）, and the diffused mesenteria hyperplasia and the in- crease of intercapillary cells in the model group were showed in the pathological sections. After 3 weeks of treat ment. The Scr of （99. 82±9.29） μmol/L, BUN of （6.32±0.75） rental/Land24 h UPof （189.67±15.45） mg/ 24 h in the acupuncture group were all decreased significantly, furthermore, the decrease of BP, HR, NE were better than the other treatment groups （P〈0.05, P〈70.01）. Except the level of 24 h up and HR at 8th week. other results were as same as the 3rd week. Conclusion Acupuncture can improve the function of kidney, decrease the content of 24 h UP and the underlying therapeutic mechanism could be correlated with that acupuncture can lower excitabil