中文摘要：

目的：研究土槿乙酸抗肿瘤作用的构效关系。方法：以土槿乙酸为原料，合成8个土槿乙酸衍生物，其结构经IH—NMR，MS证实。经MTT法筛选了衍生物的抗肿瘤活性。结果：8个化合物均为新化合物，除Ⅱc所有化合物均具有抗肿瘤活性，其中Ⅱf，Ⅱg的抗肿瘤活性显著高于土槿乙酸。结论：某些土槿乙酸酯和酰胺可提高抗肿瘤活性。

英文摘要：

Objective： To study the relationship between the Pseudolaric acid B structure and its antitumor activity. Methods： 8 derivatives of Pseudolaric acid B have been synthesized in this paper. Their structures were conformed by 1H - NMR,MS. The antitumor activity of the derivatives were determined by MTT methods. Results： All the 8 derivatives were not reported by previous literature. Results showed the antitumor activity of the derivatives approach to Pseudolaric acid B , the antitumor activity of the derivatives Ⅱf, g are better than Pseudolaric acid B. Conclusion： some esters and amids de of Pseudolaric acid B are necessary group in antitumor activity.