位置：成果数据库 > 期刊 > 期刊详情页
Distributed implementation of the genetic double-branch structure in Escherichia coli
  • ISSN号：1001-6538
  • 期刊名称：Chinese Science Bulletin
  • 时间：2014
  • 页码：4625-4630
  • 分类：Q78[生物学—分子生物学] TP393[自动化与计算机技术—计算机应用技术;自动化与计算机技术—计算机科学与技术]
  • 作者机构：[1]Key Laboratory of High Confidence Software Technologies ofMinistry of Education, School of Electronics Engineering andComputer Science, Peking University, Beijing 100871, China, [2]School of Information Engineering, Minzu University of China,Beijing 100081, China
  • 相关基金：supported by the National Basic Research Program of China(2013CB329601 and 2013CB329602);the National Natural Science Foundation of China(61127005,60974112,30970960,60910002,60971085,and 61100055)
  • 相关项目：自组装DNA纳米芯片分子信号综合检测系统
作者： Chen, Mei|Zhang, Lu|Xu, Jin|
关键词： 分布式系统, 分支结构, 大肠杆菌, 遗传, 控制单元, 生物计算, 计算系统, 数学模型, Biological computing, Double-branch structure - Cell-cell communication, Distributed computation
中文摘要：

因为房间的简洁，造生物计算系统的关键可以在基于 cellcell 通讯构造分布式的系统躺着。由一个数学模型指导了，在我们设计了，模仿，并且构造在细菌 Escherichia coli 的基因双分支结构的这研究。这基因双分支结构由一个控制房间和二个记者房间组成。控制房间能根据输入激活不同记者房间。二个察觉到治安法官的信号分子， 3OC12-HSL 和 C4-HSL，形成在控制房间和记者房间之间的电线。这研究是向可伸缩的生物计算的步，并且它可以在 biocomputing， biosensing，和 biotherapy 有许多潜在的应用。

英文摘要：

Because of the simplicity of cells, the key to building biological computing systems may lie in constructing distributed systems based on cell-cell communication. Guided by a mathematical model, in this study we designed, simulated, and constructed a genetic double-branch structure in the bacterium Escherichia coli. This genetic double-branch structure is composed of a control cell and two reporter cells. The control cell can activate different reporter cells according to the input. Two quorum-sensing signal molecules, 3OC12- HSL and C4-HSL, form the wires between the control cell and the reporter cells. This study is a step toward scalable biological computation, and it may have many potential applications in biocomputing, biosensing, and biotherapy.

同期刊论文项目
大规模图信息处理DNA计算模型研究
期刊论文 15
纳米型图信息处理DNA计算模型研究
期刊论文 27 会议论文 11
感觉传入在海马的整合及可塑性
期刊论文 3
自组装DNA纳米芯片分子信号综合检测系统
期刊论文 29 会议论文 3
活体生物分子计算模型的一些研究与探索
期刊论文 23 会议论文 8
基于组合约束和热力学约束的DNA计算核酸序列设计研究
期刊论文 23 会议论文 5 著作 1
同项目期刊论文
生物计算机时代即将来临
极大平面图理论研究进展
图顶点着色问题的DNA计算模型
MolecularLogic Computing Model based on Self-Assembly of DNA Nanoparticles
Prediction of interspecies transmission for avian influenza A virus based on a back-propagation neur
图的最大团与最大独立集粘贴DNA计算模型
molecular logic computing model based on self-assembly of dna nanoparticles
生物计算机时代即将来临
微流控DNA计算的研究进展及展望
一种新型DNA自组装磁珠光电检测系统及其在DNA计算机研制中的应用
最小支配集问题的活体分子计算模型
最小支配集的活体分子计算模型
自组装DNA/纳米颗粒分子逻辑计算模型
基于动态依赖的类间测试顺序研究
极大平面图理论研究进展
可满足性问题生物砖翻转细胞计算模型
多重Mycielski图的点可区别全染色
若干联图的邻点可区别I-全染色
基于群体决策自主控制的街道照明系统
S_m∨F_n的邻点可区别Ⅰ-全染色及相关结论
图顶点着色问题的DNA计算模型
图的最大团与最大独立集粘贴DNA计算模型
molecular logic computing model based on self-assembly of dna nanoparticles
微流控DNA计算的研究进展及展望
一种新型DNA自组装磁珠光电检测系统及其在DNA计算机研制中的应用
最小支配集问题的活体分子计算模型
DNA计算技术的发展与应用
Molecular logic computing model based on DNA self-assembly strand branch migration
自组装DNA/纳米颗粒分子逻辑计算模型
自组装DNA链置换分子逻辑计算模型
可满足性问题生物砖翻转细胞计算模型
可满足性问题的巨磁电阻型DNA计算模型
A Novel Exact Algorithm for Graph Coloring via Implicit Enumeration
Multiobjective Genetic Algorithm for Optimized DNA Sequences for DNA Self-assembly
基于两级下料和动态修正的配料称量控制模型
Solving Subset Sum Problems by Time-free Spiking Neural P Systems
A Novel Genetic Algorithm for Nucleic Acid Secondary Structure Prediction with Planar Pseudoknots
<span>Bilinear Grid Search Strategy Based Support Vector Machines Learning Method</span>
<span>Solving Graph Coloring Problem by Parallel Genetic Algorithm Using Compute Unified Devic
The Finite Languages Generated by Spiking Neural P Systems with Astrocytes
Mass segmentation using a combined method for cancer detection
基于行为模型的需求可视化研究
A Comparison of Contrast Measurements in Passive Autofocus Systems for Low Contrast Images
<span>A Hybrid Distribution Algorithm Based on Membrane Computing for Solving the Multiobjecti
Parallel Genetic Algorithm with OpenCL for Traveling Salesman Problem
A Dynamic Programming Algorithm for Circular Single-stranded DNA Tiles Secondary Structure Predictio
基于动态依赖的类间测试顺序研究
混合方式数据验证方案的研究
钢材性能与工艺参数的交叉预测模型研究
可满足性问题生物砖翻转细胞计算模型
一种三维地下巷道建模的改进方法
基于衰减窗口的通讯录搜索技术
Selective Control of Gold Nanoparticles based on Circular DNA Strand Displacement
A Molecular Logical Switch beacon controlled by thiolated DNA signals
A P-based hybrid evolutionary algorithm for vehicle routing problem with time windows
Uniform solution to common algorithmic problem by P systems working in the minimally parallel mode
Development of DNA computing and information processing based on DNA-strand displacement
On dominating sets of maximal outerplanar and planar graphs
A note on local coloring of graphs
生物计算机时代即将来临
Coritivity-based influence maximization in social networks
A molecular cryptography model based on structures of DNA self-assembly
DNA计算技术的发展与应用
A molecular logical switching beacon controlled by thiolated DNA signals
A novel membrane algorithm for capacitated vehicle routing problem
Rational construction of a cellular memory inverter
Construction of a genetic conditional learning system in Escherichia coli
Molecular logic computing model based on DNA self-assembly strand branch migration
自组装DNA链置换分子逻辑计算模型
图顶点着色问题的DNA计算模型
基于环形DNA分子的一种求解最大集团的计算模型
Development of an in vivo computer for SAT Problem
图的最大团与最大独立集粘贴DNA计算模型
Prediction of Interspecies Transmission for Avian Influenza A Virus Based on BP Neural Network
molecular logic computing model based on self-assembly of dna nanoparticles
体内生物分子计算系统的原理、进展和展望
微流控DNA计算的研究进展及展望
一种新型DNA自组装磁珠光电检测系统及其在DNA计算机研制中的应用
最小支配集问题的活体分子计算模型
DNA计算机原理、进展及难点(V):DNA分子的固定技术
冠状动脉粥样硬化性心脏病冠脉循环建模与仿真
改进区域生长法及其在冠状动脉造影图中的应用
Improved method for predicting protein fold patterns with ensemble classifiers
自组装DNA/纳米颗粒分子逻辑计算模型
可满足性问题生物砖翻转细胞计算模型