中文摘要：

目的应用超声光散射断层成像分析不同大小的乳腺病灶的总血红蛋白浓度（THC）特征、病灶大小与THC的相关性。方法采用常规超声和超声光散射乳腺断层成像系统，前瞻性研究277例患者共306个乳腺病灶，并与手术病理对照。测量光吸收参数THC，分析病灶大小与THC的相关性，并比较不同大小的组间THC是否有差异。结果306个乳腺病变中，良性147个，恶性159个，良性病灶THC均值（137．36±90．43）μmol／L，恶性病灶THC均值（227．36±88．53）μmol／L，差异有统计学意义（P〈0．001）。THC与病灶大小呈正相关，但良性组相关性明显小于恶性组（相关系数0．187vs0．454）。恶性组病灶大小与THC呈线性相关，直线回归方程为Y=143．430＋40．785X。结论乳腺病灶大小与THC测值有相关性，恶性病变的THC与病灶大小呈线性相关，而良性病灶THC测值受病灶大小影响较小。

英文摘要：

Objective To investigate the features of total hemoglobin concentration （THC） in breast lesions of different sizes as well as the correlation between lesion size and THC with diffused optical tomography （DOT）. Methods Conventional ultrasonography and DOT were performed on 306 breast lesions in 277 patients, and the results were compared with pathological findings. THC was measured, and the correlation between the lesion size and THC was evaluated. The lesions were classified into several groups according the sizes, and the differences between each group were evaluated. Results There were 147 benign and 159 malignant lesions. The mean THC was （137.36±90.43）μmol/L in the benign, and （227.36± 88.53） μmol/L in malignant lesions. There was significant difference between each group （P〈0. 001）. There was significant correlation between lesion size and THC, but the correlation of benign lesions was weaker than that of the malignant lesions （correlation coefficient： 0. 187 vs 0. 454）. In the malignant lesions, the linear regression equation of lesion size and THC was; Y=143. 430＋40. 785X. Conclusion There is correlation between lesion size and THC in breast lesions. THC of malignant breast lesions has linear correlation with lesion size, but the lesion size has little effect on THC of benign ones.