中文摘要：

就三磷酸腺苷结合盒转运体Al（ABCAl）的结构、功能及调控研究的最新进展作一综述.ABCAl是一种膜整合蛋白,它具有多种复杂的功能,能介导细胞内磷脂和胆固醇流出到贫脂载脂蛋白A-Ⅰ,并且在高密度脂蛋白代谢过程中起重要作用.人类ABCAl变异将引起严重的高密度脂蛋白不足,其特征为载脂蛋白A-Ⅰ和高密度脂蛋白缺陷以及动脉粥样硬化.ABCAl的表达受到多种物质高度调控.细胞核受体主要通过作用于ABCAl启动子DR4元件参与调节ABCAl表达.第二信使环磷酸腺苷通过作用于转录水平和翻译水平上调ABCAl表达.细胞因子对ABCAl转录具有多效性和矛盾效应.除此以外,各种蛋白质和酶类如蛋白激酶A,蛋白激酶CK2,组织蛋白酶D也参与ABCAl表达调控.

英文摘要：

ATP-binding cassette transporter A1（ABCA1） is a kind of membrane intergrate protein and may have multiple and diverse functions. It mediates the cellular efflux of phospholipids and cholesterol to lipid-poor apolipoproteinA- Ⅰ （apoA- Ⅰ ） and plays a significant role in high density lipoprotein （HDL） metabolism. Mutations in human ABCAl cause severe HDL deficiencies characterized by the virtual absence of apoA- Ⅰ and HDL and prevalent atherosclerosis. ABCAl expression is highly regulated and implies a variety of molecular actors. All of the nuclear receptors which involve in regulation of ABCAl expression act via the DR4 element in the ABCAl promoter. cAMP up-regulates ABCAl expression by acting both at the transcriptional and translational level. Cytokines have been shown to exert pleiotropic and antinomic effects on ABCAl transcription, In addition to these, some of enzymes and proteins such as protein kinase A, protein kinase CK2, cathepsin D are involved in the regulation of ABCAl expression. The recent progress in the structure, function and regulation of ABCA1 transporter is reviewed.