中文摘要：

目的：观察基于＂血分蕴毒＂理论的银屑病优化方——凉血解毒方、养血解毒方和活血解毒方对咪喹莫特诱导银屑病样小鼠模型的干预作用。方法：48只BALB/c小鼠随机均分为正常对照组、模型组、凉血解毒组、养血解毒组、活血解毒组、阳性对照（雷公藤多苷）组。观察银屑病样小鼠模型皮损变化情况、形态学变化;检测增殖细胞核抗原（PCNA）、CD3、Involucrin改变。结果：模型组小鼠皮出现红斑、鳞屑、皮肤增厚等类似银屑病样皮损。凉血解毒组和养血解毒组小鼠皮损症状缓解,皮损面积和疾病严重程度（PASI）分数降低,表皮角化不全减轻,角质形成增殖减少,T淋巴细胞浸润减弱,但活血解毒组的缓解效果较弱。结论：凉血解毒方和养血解毒方可显著改善咪喹莫特诱导的小鼠银屑病样皮损,抑制表皮细胞增生、异常分化、炎细胞浸润等主要银屑病样病理表现;活血解毒方作用不及前两者。

英文摘要：

Objective： To observe the effects of three modified psoriasis prescriptions based on the theory of toxin accumulation in blood： Liangxue Jiedu Decoction, Yangxue Jiedu Decoction and Huoxue Jiedu Decoction on mice psoriasis- like lesions induced by Imiquimod （IMQ）. Methods： Forty-eight BALB/c mice were randomly divided into six groups： control group, model group, Liangxue Jiedu group, Yangxue Jiedu group, Huoxue Jiedu group and Tripterygium glycosides group. The lesions, histology and epidermal thickness were observed. The proliferating cell nuclear antigen （PCNA）, CD3, involucrin were detected. Results： Compared with model group, the cutaneous symptoms of Liangxue Jiedu group and Yangxue Jiedu group were alleviated, with PASI scores decreased, epidermal parakeratosis and epidermal over-proliferation relieved, the numbers of dermal T lymphocytes reduced significantly. Conclusion： Liangxue Jiedu Decoction and Yangxue Jiedu Decoction could regulate the imiquimod-induced murine psoriasis-like lesions and inhibit the symptoms of psoriasis such as keratinocytes over-proliferation, parakeratosis and inflammatory infiltration; while the effects of Huoxue Jiedu Decoction is not as effective as Liangxue Jiedu Decoction and Yangxue Jiedu Decoction.