中文摘要：

目的：总结声音嘶哑为主诉患者的18 F‐FDG PET ／CT 表现，探讨其临床应用价值。方法回顾性分析2010年8月-2013年2月在本院行全身18 F‐FDG PET ／CT 检查的71例声音嘶哑患者的临床及影像学检查资料，采用视觉和半定量分析法记录导致声音嘶哑病变的类型、部位及代谢特点，并采统计学方法分析双侧声带18 F‐FDG 的影像学特征。所有导致声音嘶哑的病变均经喉镜／支气管镜检查、典型影像学表现及临床随访证实；所有良性病变及原发恶性病变均经病理证实。结果（1）导致声音嘶哑的病变主要来源于非医源性病变（占93．0％，66／71），其中以恶性病变为主（占95．5％，63／66）；（2）根据导致声音嘶哑病变的部位分为两组：①直接侵犯组13例（直接侵犯喉部肌肉），包括原发恶性病变7例、转移灶侵犯声门区3例及良性病变3例；②神经侵犯组58例（侵犯压迫对应神经），包括恶性病变53例与术后和（或）放疗后病变5例。（3）声带的影像学表现：①直接侵犯组中，CT 表现示受累侧声带增厚或伴软组织肿块影，位置固定；PET 表现示91．67％（11／12）单侧声带受累患者的患侧声带出现 FDG 摄取增高，患侧声带与健侧声带的 SUVmax 有显著性差异（ P ＜0．05）；②神经侵犯组中，CT 表现示受累侧声带松弛外展；PET 表现示98．2％（54／55）单侧声带受累患者的健侧声带出现 FDG 摄取增高，患侧声带与健侧声带的 SUVmax 有极显著性差异（ P ＜0．001）。然而，直接侵犯组的患侧声带与神经侵犯组的健侧声带的 SUVmax 无显著性差异（ P ＞0．05）。结论全身多种病变可以导致声音嘶哑，颈胸部恶性病变（如肺癌或食管癌伴纵隔淋巴结转移）为最常见原因。 PET ／CT 不仅可以显示声带的非对称性 FDG 摄取，而且可以显示声音嘶哑的病因，帮助寻找原发灶，为声音嘶

英文摘要：

sions and 5 radiation therapy for neck lesions and postoperation .（3） The imaging mainfestation of vocal cords ： ① In direct invasion group （n = 13） ,12 cases of unilateral vocal cord affected ,CT showed ipsilateral vocal cord thickening or with presence of a submucosal mass fixed in laryngeal area .Higher FDG uptake in the affected vocal cord was seen in 91 .67%（11/12） .It showed statistically difference in FDG accu mulation between affected and unaffected vocal cord ; ② In Nerve invasion group （n = 58） ,55 cases of unilateral vocal cord affected ,CT showed ipsilateral vocal cord relaxed ,the perform‐ance of vocal cord also applied to bilateral affected vocal cord .Higher FDG uptake in the unaffected vocal cord was seen in 98 .2% （54/55） in patients .It showed statistically significant difference in FDG accumulation between affected and unaf‐fected vocal cord .In addition ,no statistically significant difference was shown in the FDG accumulation between affected vocal cord of Direct invasion group and affected vocal cord of Nerve invasion group .Conclusion Hoarseness can be caused by multiple lesions ,of which neck and thoracic malignant lesions are the most common reasons ,expecially lung cancer or esophageal cancer with mediastinal lymph node metastases .PET /CT can not only display asymmetrical fluorodexyglucose （FDG） uptake of vocal cord ,of which usually direct invasion group shows ipsilateral vocal cord with increased metabo‐lism ,whereas nerve invasion group shows contralateral vocal cord with increased metabolism ,but also show the main rea‐son for hoarseness ,which can aid to find the primal tumor and provide information of clinical diagnosis and treatment of the diseases .