目的:观察不同治疗方法治疗喘憋性支气管肺炎的临床疗效。方法:喘憋性支气管肺炎患儿120例随机分为常规治疗组、全身激素治疗组、激素雾化吸入治疗组和维生素K1治疗组。常规治疗组主要以抗感染、止咳化痰对症处理为主,其余3组在常规治疗基础上,全身激素治疗组加用琥珀酸氢化可的松(50 mg/kg),每日静滴1次,连用5天停用;激素雾化吸入治疗组加用布地奈德0.5 mg,雾化吸入,每天2次,连用5天停用;维生素K1治疗组加用维生素K1,每次0.3~0.5 mg/kg,每天2次,连用5天停用,观察临床疗效及副作用。结果:4组治疗后症状评分均明显改善,与常规治疗组相比,全身激素治疗组、激素雾化吸入治疗组及维生素K1治疗组3组症状改善更明显(P〈0.05)。全身激素治疗组显效率69%,有效率21%,无效率10%,总有效率90%;糖皮质激素雾化吸入治疗组显效率72%,有效率19%,无效率9%,总有效率91%;维生素K1治疗组显效率57%,有效率29%,无效率14%,总有效率86%,均高于常规治疗组(显效率32%,有效率29%,无效率39%,总有效率61%),差异有统计学意义(P均〈0.05)。结论:全身激素治疗及激素雾化吸入治疗疗效显著,维生素K1疗效与激素疗效接近。对于不接受或不能使用激素治疗的喘憋性支气管肺炎患儿,全身使用维生素K1也可作为平喘的治疗方法。
Objective:To observe the clinical efficacies of different therapies for asthmatic suffocating bronchopneumonia(ASP).Methods:One hundred and twenty children with ASP were divided into conventional therapy group,systematic hormone therapy group,hormone atomization inhalation therapy group,and vitamin K1 therapy group randomly.The children in conventional therapy group were treated with symptomatic treatment,such as anti-infection,stopping cough,and eliminating phlegm;on the basis of conventional therapy,the children in systematic hormone therapy group were treated with intravenous drip of succinate hydrocortisone(50 mg/kg) for successive five days;the children in hormone atomization inhalation therapy group were treated with atomization inhalation of budesonide(0.5 mg),twice a day for successive five days;the children in vitamin K1 therapy group were treated with vitamin K1,0.3-0.5 mg/kg per time,twice a day for successive five days.The clinical efficacies and adverse reactions were observed.Results:After treatment,symptom scores in the four groups increased significantly,compared with conventional therapy group,the improvements of symptoms in the other three groups were more obvious(P〈0.05).The obvious effective rate,effective rate,ineffective rate,and total effective rate in systematic hormone therapy group were 69%,21%,10% and 90%,respectively;the obvious effective rate,effective rate,ineffective rate,and total effective rate in hormone atomization inhalation therapy group were 72%,19%,9%,and 91%,respectively;the obvious effective rate,effective rate,ineffective rate,and total effective rate in vitamin K1 therapy group were 57%,29%,14%,and 86%,respectively.The obvious effective rate,effective rate,ineffective rate,and total effective rate in the above-mentioned three groups were all significantly higher than those in conventional therapy group(obvious effective rate(32%),effective rate(29%),ineffective rate(39%),and total effective rate(61%))(P〈0.05).Conclusion?