中文摘要：

p53介导由胞内压力诱导的细胞凋亡等多种细胞应答。传统上认为，p53主要在细胞核内作为转录因子调控多种促凋亡靶基因的表达，从而发挥其促凋亡功能。而最新的研究表明，p53也能直接在细胞质中发挥其促凋亡作用，并且该过程不依赖于其核内的转录活性。此外，在特定的刺激下，p53的转录依赖性（细胞核内）与转录非依赖性（细胞质内）促凋亡作用存在着偶联和协同机制，从而有效的决定细胞在生存与死亡间进行选择。现对近年来关于细胞凋亡中p53转录依赖性和转录非依赖性调控及它们之间的偶联机制的研究进行综述。

英文摘要：

p53 plays a key role in mediating various cell responses such as apoptosis to cellular stresses. Traditionally, the apoptogenic effects of p53 are ascribed to its transactivation activities in the nucleus. However, growing evidence has elucidated that cytoplasmic p53 can trigger apoptosis independent of its transactivation activity through sub-cellular translocation and activation of pro-apoptotic Bcl-2 family members. Coordination of the transcription dependent and independent functions of p53 contributes to cell ultimate response to stress, making a final decision between cell survival and death. In this paper we review the latest progress on the two different functions of p53 in apoptosis regulation and gave a unified model describing the cooperation between the nuclear and cytoplasmic pro-apoptotic function of p53.