中文摘要：

从鼻咽的癌或乳癌为骨头转移的治疗与蒙特卡罗(MC ) EGS4 方法计算 153Sm-EDTMP 的焦点吸收剂量，并且调查在杀死的焦点吸收剂量和疼痛之间的关系的目的 153Sm-EDTMP 完成。方法有多重骨头转移从的四个病人鼻咽或胸癌并且患了等级 IV 骨头疼痛与放射性核种被对待 153Sm-EDTMP 的内部照耀。骨头转移和另外的指向的机关的吸收剂量和剂量分发在尿累积基于扫描的时间顺序 SPECT/CT 和放射性的测量用 MC EGS4 节目被计算。骨头疼痛的版本和生活质量的改进被观察。病人的结果骨头疼痛显著地被减轻在内部 153Sm-EDTMP 照耀以后分级 II 3 4 个星期。骨头转移和指向的机关的 3-dimensional 吸收剂量分发图象证明在骨头转移的剂量分发不是不均匀的。在 0.65 ×的注射以后 37 MBq/kg 153Sm-EDTMP，在骨头损害的最高的吸收剂量在损害边缘是大约 4.9 5.9 Gy，和剂量是大约 2.0 Gy。用参考开点的最高的剂量，相对吸收在损害附近开骨髓，椎骨和性机关的价值分别地是 0.48 1.1 Gy， 0.51 0.85 Gy，和 0.01 0.14 Gy。吸收骨头转移开的结论是比在 153Sm-EDTMP 的单个照耀以后的 30 Gy 的治疗剂量显著地低的。杀死效果的疼痛被限制并且根据临床的观察。

英文摘要：

Objective： To calculate the focus absorption dose of ^153Sm-EDTMP with the Monte Carlo （MC） EGS4 method for treatment of bone metastases from nasopharyngeal carcinoma or breast cancer, and investigate the relationship between the focus absorption dose and painkilling effect of ^153Sm-EDTMP. Methods： Four patients with multiple bone metastases from nasopharyngeal or breast carcinoma and suffered from grade IV bone pain were treated with radionuclide internal irradiation of ^153Sm-EDTMP. The absorption dose and dose distribution of bone metastases and other targeted organs were calculated with MC EGS4 program based on the time-order SPECT/CT scanning and the measurement of the radioactivity in the urine accumulation. The release of bone pain and the improvement of life quality were observed. Results： Bone pain of the patients was significantly alleviated to grade II for 3-4 weeks after internal ^153Sm-EDTMP irradiation. The 3-dimensional absorption dose distribution image of bone metastases and targeted organs showed that the dose distribution in bone metastases was not asymmetrical. After injection of 0.65 × 37 MBq/kg ^153Sm-EDTMP, the highest absorption dose in bone lesions was about 4.9-5.9 Gy, and the dose in the lesion margin was about 2.0 Gy. Using the highest dose as reference dose point, the relative absorption dose values of bone marrow, vertebra and sex organ near lesions were 0.48-1.1 Gy, 0.51-0.85 Gy, and 0.01-0.14 Gy, respectively. Conclusion： The absorption dose of bone metastases is significantly lower than treatment dose of 30 Gy after single irradiation of ^153Sm-EDTMP. The painkilling effect is limited and in accordance with clinical observation.