中文摘要：

瞄准：在在兔子肝 VX-2 肿瘤的 chemoembolization 当模特儿以后，在先生散开加权的成像(DWI ) 上调查在 PCNA， Bax， nm23， E-cadherin 表示和明显的散开系数(模数转换器) 之间的动态特征和关联。方法：四十个新西兰兔子肝 VX-2 肿瘤模型在学习被包括。DWI 在 chemoembolization 以后周期性地被执行。在每个组的所有 VX-2 肿瘤样品被组织病理学说和 Strept Avidin-Biotin 建筑群(SABC ) 免疫检验组织化学的染色。结果：在 VX-2 肿瘤的 PCNA 表示索引比在在肿瘤附近的正常实质高(P 【 0.001 ) 。在 VX-2 肿瘤的 Nm23， Bax 或 E-caderin 表示索引是比在在肿瘤附近的正常实质低的(所有 P 【 0.001 ) 。在 VX-2 肿瘤圆周的 PCNA 和 nm23 表示首先增加了然后减少(P 【 0.001 并且 P = 0.03，分别地) ，当在 chemoembolization 前后的 Bax 和 E-cadherin 的表示是不足道的时。当 b 值是 100 s/mm2 时，在 VX-2 肿瘤圆周的区域在 PCNA 表示和模数转换器之间有一道直线相关(P 【 0.001 ) ，并且在 VX-2 肿瘤圆周的 PCNA 表示影响了模数转换器。结论：VX-2 肿瘤渗透并且转移的潜力减少，当它增殖的能力在 chemoembolization 以后在一短时间增加时。在某种程度上， ADC 价值间接地反映 VX-2 肿瘤房间的增长。

英文摘要：

AIM： To investigate the dynamic characteristics and the correlation between PCNA, Bax, nm23, E-cadherin expression and apparent diffusion coefficient （ADC） on MR diffusion-weighted imaging （DWI） after chemoembolization in rabbit liver VX-2 tumor model. METHODS： Forty New Zealand rabbit liver VX-2 tumor models were included in the study. DWI was carried out periodically after chemoembolization. All VX-2 tumor samples in each group were examined by histopathology and Strept Avidin-Biotin Complex （SABC） immunohistochemical staining. RESULTS： The PCNA expression index in VX-2 tumors was higher than in the normal parenchyma around the tumor （P 〈 0.001）. Nm23, Bax or E-caderin expression index in VX-2 tumors were lower than in the normal parenchyma around the tumor （all P 〈 0.001）. PCNA and nm23 expression in the VX-2 tumor periphery first increased and then decreased （P 〈 0.001 and P = 0.03, respectively）, while the expression of Bax and E-cadherin before and after chemoembolization was insignificant. When b-value was 100 s/mm^2, there was a linear correlation between PCNA expression and ADC in the area of VX-2 tumor periphery （P 〈 0.001）, and PCNA expression in VX-2 tumor periphery influenced the ADC. CONCLUSION： The potential of VX-2 tumor infiltrating and metastasizing decreases, while its ability to proliferate increases for a short time after chemoembolization. To some degree, the ADC value indirectly reflects the proliferation of VX-2 tumor cells.