中文摘要：

目的 比较不同中医证型溃疡性结肠炎（ UC）患者癌变危险因素的差异。方法 选择UC住院患者71例，按中医辨证分为脾胃气虚证组35例和湿热内蕴证组36例，对2组患者的基本信息、临床症状、肠镜表现及组织病理学改变进行回顾性分析。结果 脾胃气虚证组平均病程（69．3个月）较湿热内蕴证组（24．7个月）更长。脾胃气虚证组26％的患者病程超过10 a，与湿热内蕴证组（6％）比较差异有统计学意义（P＝0．019）；发生全结肠炎的患者脾胃气虚证组（7例）较湿热内蕴证组（3例）更多，但差异无统计学意义（ P＝0．905）；湿热内蕴证组患者肠黏膜主要表现为中、重度充血、水肿、质脆（47％），中、重度糜烂（29％）；脾胃气虚证组患者以无明显或呈轻度充血、水肿、质脆为主（86％），糜烂也多呈轻度（91％），2组比较差异有统计学意义（P＝0．001，P＝0．042）。2组发生异型增生的病例均呈低级别异型增生，脾胃气虚证组（8例）多于湿热内蕴证组（3例），但差异无统计学意义（P＝0．065）。结论 从病程、病变范围、炎症程度及异型增生的角度，看溃疡性结肠炎脾胃气虚证具有癌变危险因素的患者比例明显高于湿热内蕴证，但脾胃气虚证患者中是否有更多患者发生了癌前病变或癌变，还有待长期的随访研究。

英文摘要：

Objective It is to compare the differences in cancer risk factors between different Chinese traditional medical syndromes of ulcerative colitis （ UC） .Methods 71 patients with UC in hospital were divided into two groups according to different Chinese medicine syndrome types：spleen Qi and stomach Qi deficiency syndrome（35 cases）and internal accumulation of dampness-heat syndrome（36 cases）.The patients＆#39;personal data,clinical symptoms,colonoscopy performance and histopathological features were analyzed retrospectively.Results The average duration in spleen Qi and stomach Qi deficiency syndrome group was 69.3 months,which was longer than that was 24.7 months in dampness-heat syndrome group.26% patients had been diagnosed with UC for more than 10 years in spleen Qi and stomach Qi deficiency syndrome group,which was higher than the dampnessheat syndrome group（6%）,there was a significant difference between the two groups（P=0.019）.Although no significant difference was found,the number of pancolitis in spleen Qi and stomach Qi deficiency syndrome group（7 cases）was higher than that in the another group（3 cases）.The extent of intestinal mucosal congestion,edema,crisp（47%）and erosion （29%）in the dampness-heat syndrome group were moderate and severe,which were no or mild in the spleen Qi and stomach Qi deficiency syndrome group（86%and 91%） ,there were statistically significant differences between the two syndrome groups （P=0.001,P=0.042）.8 cases in the spleen Qi and stomach Qi deficiency syndrome group and 3 cases in the dampness-heat syndrome（P=0.065）were diagnosed with mucosal dysplasia,and the difference was not significant （P=0.065）,all pa-tients with dysplasia were low grade dysplasia.Conclusion From the view of duration, extent, inflammation and dysplasia, the proportion of patients with CAC risk factors in the spleen Qi and stomach Qi deficiency syndrome group was higher than those in the dampness-heat syndrome group.A long-term follow-up survey was still nee